Thomas Fabre

Learn More
Loss of CD4 T cell help correlates with virus persistence during acute hepatitis C virus (HCV) infection, but the underlying mechanism(s) remain unknown. We developed a combined proliferation/intracellular cytokine staining assay to monitor expansion of HCV-specific CD4 T cells and helper cytokines expression patterns during acute infections with different(More)
Activation of hepatic stellate cells (HSCs) is a key event in the initiation of liver fibrosis, characterized by enhanced extracellular matrix production and altered degradation. Activation of HSCs can be modulated by cytokines produced by immune cells. Recent reports have implicated the proinflammatory cytokine IL-17A in liver fibrosis progression. We(More)
H epatic stellate cells (HSCs) are nonparenchymal cells located at the interface between hepatocytes and liver sinusoidal endothelial cells. HSCs are quiescent under normal conditions and play an important role in the uptake and metabolism of vitamin A. Their activation by cytokines and inflammatory signals secondary to liver injury or inflammation(More)
Single nucleotide polymorphisms (SNPs) in the proximity of the interleukin-28B (IL28B) gene can predict spontaneous resolution of hepatitis C virus (HCV) infection and response to interferon therapy. Screening for this polymorphism has become part of the standard criteria for the management of HCV-infected patients, hence the need for a rapid,(More)
Nonalcoholic fatty liver disease (NAFLD) is now the most common progressive liver disease in developed countries and is the second leading indication for liver transplantation due to the extensive fibrosis it causes. NAFLD progression is thought to be tied to chronic low-level type 1 inflammation originating in the adipose tissue during obesity; however,(More)
HIV-infected slow progressors (SP) represent a heterogeneous group of subjects who spontaneously control HIV infection without treatment for several years while showing moderate signs of disease progression. Under conditions that remain poorly understood, a subgroup of these subjects experience failure of spontaneous immunological and virological control.(More)
We have realized very recently that two of the primer sets and PCR conditions described in the paper unintentionally listed the sequences of two earlier sets of primers that were suboptimal. The final primer sets and PCR conditions used to generate all the data in the paper are now listed in a revised version of Table 1 (below). This revised set of primers(More)
Twenty nonconserving retarded adults were assigned to equated training and control groups (n = 10 in each group). Training-group subjects were given multiple-strategy training for number conservation consisting of: demonstrating effects of addition-subtraction; negation of addition-subtraction by inverse operations; and addition-subtraction combined with(More)
  • 1