Thomas F . Smith

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The identification of maximally homologous subsequences among sets of long sequences is an important problem in molecular sequence analysis. The problem is straightforward only if one restricts consideration to contiguous subsequences (segments) containing no internal deletions or insertions. The more general problem has its solution in an extension of(More)
In addition to the sequence homologies and statistical patterns identified among numerous genetic sequences, there are subtler classes of patterns for which most current computer search methods offer very limited utility. This class includes various presumptive eukaryotic regulatory sites. A critique of the often employed consensus and local homology(More)
Real-time PCR has revolutionized the way clinical microbiology laboratories diagnose many human microbial infections. This testing method combines PCR chemistry with fluorescent probe detection of amplified product in the same reaction vessel. In general, both PCR and amplified product detection are completed in an hour or less, which is considerably faster(More)
Pneumocystis carinii pneumonia has emerged as a significant cause of morbidity and mortality in immunocompromised patients with and without AIDS. To determine differences in P. carinii pneumonia in patients with and without AIDS, the P. carinii parasite numbers, lung inflammatory cell populations, gas exchange, and survival were assessed in a series of 75(More)
  • LibraryD . Andresen, Larry Carver, +12 authors Q . ZhengAlexandria
  • 1995
The Alexandria Digital Library (ADL) is focussed on providing broad access to distributed collections of spatially-indexed information. ADL has a four-component architecture involving collections , catalog, interfaces, and ingest facilities. The rst stage in the construction of ADL resulted in the design and implementation of a rapid prototype (RP) system.(More)
A metric on binary trees is dehed to give the similarity of two dendrograms. One of the major desirable properties of the proposed treesimilaritymeasure is to clarify the decision ordering nature of biological trees. This metric is applied to evolutionary tree reconstructions and comparative embryogenesis. The mathematical properties of this metric are(More)
A plaque assay system has been developed for types A and B influenza viruses in an established line of canine kidney cells (MDCK-USD). In addition to a homogeneous susceptible cell, consistent plaque production depends on the use of highly purified agar (Agarose). This quantitative system was used to determine the rate of adsorption, synthesis, and thermal(More)
The object of this paper is to give algorithms and techniques for computing generating functions of certain RNA configurations. Combinatorics and symbolic computation are utilized to calculate the generating functions for small RNA molecules. From these generating functions, it is possible to obtain information about the bonding and structure of the(More)