Thomas E. Rohan

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The insulin-like growth factors (IGFs) are mitogens that play a pivotal role in regulating cell proliferation, differentiation, and apoptosis. The effects of IGFs are mediated through the IGF-I receptor, which is also involved in cell transformation induced by tumor virus proteins and oncogene products. Six IGF-binding proteins (IGFBPs) can inhibit or(More)
The association between anthropometric indices and the risk of breast cancer was analyzed using pooled data from seven prospective cohort studies. Together, these cohorts comprise 337,819 women and 4,385 incident invasive breast cancer cases. In multivariate analyses controlling for reproductive, dietary, and other risk factors, the pooled relative risk(More)
Acquisition and clearance of cervical human papillomavirus (HPV) infection were analyzed among 1425 low-income women attending a maternal and child health program in São Paulo, Brazil. Specimens collected every 4 months were tested by a polymerase chain reaction protocol (MY09/11). In all, 357 subjects were positive at least once. There were 1.3% new(More)
Although folic acid has been investigated for its potential to inhibit carcinogenesis, few epidemiologic studies have assessed the effects of intake of thiamin, riboflavin, and niacin, which may reduce cancer risk by acting as cofactors in folate metabolism or by other mechanisms. Using data from a large cohort of Canadian women, we examined the association(More)
Animal experiments and in vitro studies have shown that compounds found in tobacco smoke, such as polycyclic hydrocarbons, aromatic amines, and N-nitrosamines, may induce mammary tumors. The findings of smokingspecific DNA adducts and p53 gene mutations in the breast tissue of smokers also support the biological plausibility of a positive association(More)
BACKGROUND Epidemiologic studies have generally reported positive associations between alcohol consumption and risk for colorectal cancer. However, findings related to specific alcoholic beverages or different anatomic sites in the large bowel have been inconsistent. OBJECTIVE To examine the relationship of total alcohol intake and intake from specific(More)
BACKGROUND The lower breast cancer incidence in minority women and the higher breast cancer mortality in African American women than in white women are largely unexplained. The influence of breast cancer risk factors on these differences has received little attention. METHODS Racial/ethnic differences in breast cancer incidence and outcome were examined(More)
Deficient dietary folate intake may predispose individuals to cancer as a consequence of disruption of DNA synthesis, repair, and methylation (1,2); diets deficient in methyl groups may result in the activation of oncogenes and inactivation of tumor suppressor genes (3). Relatively low intake of methionine and relatively high intake of alcohol may increase(More)
OBJECTIVE To examine the association between smoking and risk of invasive breast cancer using quantitative measures of lifetime passive and active smoking exposure among postmenopausal women. DESIGN Prospective cohort study. SETTING 40 clinical centres in the United States. PARTICIPANTS 79,990 women aged 50-79 enrolled in the Women's Health Initiative(More)