Thomas E. Madden

Learn More
We present a method to include robustness in a multi-criteria optimization (MCO) framework for intensity-modulated proton therapy (IMPT). The approach allows one to simultaneously explore the trade-off between different objectives as well as the trade-off between robustness and nominal plan quality. In MCO, a database of plans each emphasizing different(More)
OBJECTIVES To investigate the concentrations of carboplatin and etoposide achieved in the aqueous and vitreous humors after intravenous infusion in nonhuman primates, and to investigate whether local administration of carboplatin might result in higher concentrations in the vitreous humor. METHODS Macaca fascicularis primates were treated with 1 of 3(More)
gamma-Hydroxybutyric acid (GHB) is an abused substance that occurs naturally in the basal ganglia. Electrophysiological recordings of membrane voltage and current were made to characterize the effects of GHB on dopamine neurons in the ventral tegmental area of the rat midbrain slice. Perfusate containing GHB caused a concentration-dependent membrane(More)
Kodak's Photo CD system, originally intended for consumer applications, has been used successfully by museums and libraries to store digital images from scanned film, prints and documents. With recent advances in digital image standards and their anticipated adoption by cultural institutions, questions arise as to how best to convert Photo CD image files.(More)
Modern radiotherapy equipment is capable of delivering high precision conformal dose distributions relative to isocentre. One of the barriers to precise treatments is accurate patient re-positioning before each fraction of treatment. At Massachusetts General Hospital, we perform daily patient alignment using radiographs, which are captured by flat panel(More)
  • 1