Thomas E. Kazmierczak

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In models of early stage Parkinson's disease (PD), motor deficits are accompanied by excessive activation of striatal glutamate receptors. Metabotropic glutamate group I receptors (mGluR I) play an important but not well-understood role in PD progression. In mouse brain slices, bath application of the mGluR I agonist (RS)-DHPG (3,5-dihydroxyphenylglycine,(More)
In animal models of early Parkinson's disease (PD), motor deficits are accompanied by excessive striatal glutamate release. Blockade of group I metabotropic glutamate receptors (mGluRs), endocannabinoid degradation and nitric oxide (NO) synthesis combats PD symptoms. Activation of group I mGluRs with the specific agonist 3,5-dihydroxyphenylglycine (DHPG)(More)
The work-centered support system approach to human-centered computing focuses on analyzing and supporting the multiple facets of work. The WCSS for global weather management developed to support weather forecasting and monitoring in an airlift service organization, exemplifies this approach. A hallmark of human-centered computing (HCC) is its focus on(More)
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