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The increasing number of sequenced plant genomes is placing new demands on the methods applied to analyze, annotate, and model these genomes. Today's annotation pipelines result in inconsistent gene assignments that complicate comparative analyses and prevent efficient construction of metabolic models. To overcome these problems, we have developed the(More)
It is now recognized that enzymatic or chemical side-reactions can convert normal metabolites to useless or toxic ones and that a suite of enzymes exists to mitigate such metabolite damage. Examples are the reactive imine/enamine intermediates produced by threonine dehydratase, which damage the pyridoxal 5'-phosphate cofactor of various enzymes causing(More)
BACKGROUND In spite of its great promise, metabolomics has proven difficult to execute in an untargeted and generalizable manner. Liquid chromatography-mass spectrometry (LC-MS) has made it possible to gather data on thousands of cellular metabolites. However, matching metabolites to their spectral features continues to be a bottleneck, meaning that much of(More)
Gene fusions are the most powerful type of in silico-derived functional associations. However, many fusion compilations were made when <100 genomes were available, and algorithms for identifying fusions need updating to handle the current avalanche of sequenced genomes. The availability of a large fusion dataset would help probe functional associations and(More)
Kapitel 4: A. Pershin, S. Donets und S. A. Baeurle, " A new multiscale modeling method for simulating the loss processes in polymer solar cell nanodevices " , A multiscale modeling study of loss processes in block-copolymer-based solar cell nanodevices " through tapering the donor-acceptor interface: a multiscale study " eingereicht (2013) 4 Noch zu(More)
The Division of Molecular Biophysics I examines molecular and genomic structure problems with the help of bio-physical and computer scientific methods and develops computer simulation methods for their modelling on the genomic, molecular and electronic levels. The German EMBnet node-GENIUSnet-is a biocom-puting facility for German scientists providing(More)
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