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Twelve organic Mn sources and MnSO4 were evaluated by polarographic analysis and via solubility in buffers (pH 5 and 2) and deionized water. Fractions from solubility tests were evaluated by gel filtration chromatography for structural integrity. Organic Mn sources included five Mn methionine complexes (Mn Met A to Mn Met E), two Mn proteinates (Mn Pro A(More)
Sixty male Sprague-Dawley rats were randomly allotted to receive diets containing 5, 20 or 60% casein. Rats had access to the diet only during the initial 8 h of the daily 12-h dark period. Hepatic mitochondrial lysine uptake, lysine alpha-ketoglutarate reductase (LKR) and saccharopine dehydrogenase (SacD) activities, and in vitro lysine oxidation (LOX)(More)
A cooperative research study involving members of a regional committee (North Central Regional Committee on Swine Nutrition [NCR-42]) was conducted to assess the variability in nutrient composition (DM, CP, Ca, P, Se, and amino acids) of corn and soybean meal from 16 sources (15 states, mostly in the Midwest) and to assess the analytical variability in(More)
Grains grown in various regions of the United States vary in their innate or natural Se contents. A regional study evaluated the effects of adding inorganic Se (sodium selenite) or organic Se (Se yeast) to diets with differing innate Se contents. A 2 × 2 + 1 factorial experiment evaluating 2 Se sources (organic or inorganic) at 2 Se levels (0.15 or 0.30(More)
In rat liver, comparisons of marker enzyme activities (beta-hexosaminidase, lysosomes; catalase, peroxisomes; cytochrome oxidase, mitochondrial-inner membrane; monoamine oxidase, mitochondrial outer membrane; ornithine aminotransferase, mitochondrial matrix) show that lysine-alpha-ketoglutarate reductase and saccharopine dehydrogenase, the initial enzymes(More)
Age-related bone loss eventually leads to osteopenia in men and women. The etiology of age-related bone loss is currently unknown; however, decreased osteoblast activity contributes to this phenomenon. In turn, osteoblast proliferation and function is dependent on energy production, thus the loss of energy production that occurs with age may account for the(More)
BACKGROUND AND PURPOSE We previously reported hyperoxaluria and calcium oxalate calculi in adult pigs (sows) fed hydroxyproline (HP). The purpose of this study was to grossly and histopathologically characterize intrarenal effects in this model. METHODS In the swine facility at our campus, we maintained 21 gestating sows, of which 15 received daily(More)
Seventy-two growing pigs were fed one of nine dietary treatments that provided a range of Ca (0.4%-1.2%) and P (0.4%-1.2%) levels arranged in a two-factor central composite design. Two pigs per treatment after either 5 (T5) or 10 (T10) wk and four pigs per treatment after 15 (T15) wk were slaughtered, and the femur (F) and third (MT3) and fourth (MT4)(More)
The early onset of atherosclerotic lesions in homocystinuric individuals has implicated homocyst(e)ine in the development of atherosclerosis. Two trials were conducted in which diets totally or partially deficient in vitamin B-6 were fed to pigs to investigate the accumulation of homocyst(e)ine in the plasma and the development of vascular lesions. In one(More)
Diminishing returns responses to increments of lysine intake were evaluated in 82 crossbred barrows (10.2 +/- SE = .31 kg) fed one of six concentrations of lysine expressed as 55, 80, 90, 100, 115, or 140% of a concentration (10.9 g/kg of diet) that supported maximum weight gain. Supplemental lysine was provided from either soybean meal (SBM), SBM+synthetic(More)