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Translocation Products in Acute Myeloid Leukemia Activate the Wnt Signaling Pathway in Hematopoietic Cells
TLDR
High-density oligonucleotide arrays used to identify shared target genes in inducibly transfected U937 cells expressing AML1-ETO, PML-RARα, or PLZF-Rarα encode aberrant transcription factors, providing evidence that activation of Wnt signaling is a common feature of several balanced translocations in AML. Expand
The Cyclin A1-CDK2 Complex Regulates DNA Double-Strand Break Repair
TLDR
A novel function for cyclin A1 and CDK2 in DNA DSB repair following radiation damage is established, establishing a novel role for A-type cyclins in DNA double-strand break repair after radiation damage. Expand
Identification of Interaction Partners and Substrates of the Cyclin A1-CDK2 Complex*
TLDR
Testicular interaction partners of the cyclin A1-CDK2 complex are identified and their expression pattern in normal organs, testis development, and testicular malignancies are studied to establish a new basis for future functional analyses of cyclIn A1. Expand
Cyclin A1, the alternative A-type cyclin, contributes to G1/S cell cycle progression in somatic cells
TLDR
It is demonstrated that cyclin A1 contributes to G1 to S cell cycle progression in somatic cells and might be a therapeutic target since its silencing inhibited leukemia cell growth. Expand
Collagen metabolism is a novel target of the neuropeptide alpha-melanocyte-stimulating hormone.
TLDR
It is shown that alpha-melanocyte-stimulating hormone (alpha-MSH), a neuropeptide well known for its pigment-inducing capacity, modulates collagen synthesis and deposition and may represent a novel class of modulators with potential usefulness for the treatment of fibrotic disorders. Expand
Isolation of mak1 from Actinoplanes missouriensis and evidence that Pep2 from Streptomyces coelicolor is a maltokinase
TLDR
Sequence comparisons demonstrate that mak1‐related genes coding for homologous proteins are present in many bacterial genomes including taxonomic distantly related groups such as Rhodospirillales or green sulfur bacteria. Expand
Successive increases in human cyclin A1 promoter activity during spermatogenesis in transgenic mice.
TLDR
Data suggest that cyclin A1 is active not only in pachytene spermatocytes but also in earlier phases of sperMatogenesis, as shown in mice cloned with transgene of enhanced green fluorescent protein (EGFP). Expand
Collagen Metabolism Is a Novel Target of the Neuropeptide α-Melanocyte-stimulating Hormone*
TLDR
It is shown that α-melanocyte-stimulating hormone (α-MSH), a neuropeptide well known for its pigment-inducing capacity, modulates collagen synthesis and deposition and may represent a novel class of modulators with potential usefulness for the treatment of fibrotic disorders. Expand
The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARα and regulates differentiation of hematopoietic cells
TLDR
Protein half-life analyses and Immunohistochemistry of primary AML bone marrow biopsies suggest a role for MNK1 in the AML fusion protein-associated differentiation block, and inhibition ofMNK1 activity by a specific inhibitor enhanced differentiation of HL60 and 32D cells, further suggesting a role in myeloid differentiation. Expand
Alpha-MSH suppresses collagen synthesis 1 Collagen metabolism-a novel target of the neuropeptide alpha-melanocyte-stimulating hormone
Suppression of collagen synthesis is a major therapeutic goal in treatment of fibrotic disorders. We show here that alpha-melanocyte-stimulating hormone (alpha-MSH), a neuropeptide well known for itsExpand