Thomas C. Hennessey

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Hypothalamic neurons expressing the long form of the leptin receptor (LRb) mediate important leptin actions. Although it has been suggested that leptin crosses the blood-brain barrier (BBB) via a specific transport system, we hypothesized the existence of a population of hypothalamic arcuate nucleus (ARC) neurons that senses leptin independently of this(More)
We investigated the ability of AMP-activated protein kinase (AMPK) to activate PPARgamma coactivator-1alpha (PGC-1alpha) in the brain, liver and brown adipose tissue (BAT) of the NLS-N171-82Q transgenic mouse model of Huntington's disease (HD). In the striatum of the HD mice, the baseline levels of PGC-1alpha, NRF1, NRF2, Tfam, COX-II, PPARdelta, CREB and(More)
BACKGROUND Reduced peroxisome proliferator-activated receptor-γ coactivator 1α (PGC1α) gene expression has been observed in striatal cell lines, transgenic mouse models of Huntington's disease (HD), and brain tissue from HD patients. As this protein is a key transcription regulator of the expression of many mitochondrial proteins, these observations(More)
BACKGROUND Huntington's disease (HD) is associated with impaired energy metabolism in the brain. Creatine kinase (CK) catalyzes ATP-dependent phosphorylation of creatine (Cr) into phosphocreatine (PCr), thereby serving as readily available high-capacity spatial and temporal ATP buffering. OBJECTIVE Substantial evidence supports a specific role of the(More)
Huntington's disease (HD) is an incurable neurological disorder caused by an abnormal glutamine repeat expansion in the huntingtin (Htt) protein. In the present studies, we investigated the role of Transducers of Regulated cAMP response element-binding (CREB) protein activity (TORCs) in HD, since TORCs play an important role in the expression of the(More)
Decommissioned animal waste lagoons contain large quantities of nutrients including nitrogen (N) and phosphorus (P) and can cause pollution of nearby water resources. Using short-rotation woody crops (SRWCs) for nutrient uptake and biomass production might be an inexpensive and eco-friendly method for the stabilization of decommissioned lagoons. We(More)
Physical and mechanical properties of cardboard panels made from used beverage carton with veneer overlays. Reproductive and thyroid hormone profiles in captive western fence lizards (Sceloporus occidentalis) following a period of brumation. and W.T. Pockman. 2008. Tree die-off in response to global-change-type drought: mortality insights from a decade of(More)
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