Thomas Bradley

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BACKGROUND Despite considerable efforts within the microarray community for standardising data format, content and description, microarray technologies present major challenges in managing, sharing, analysing and re-using the large amount of data generated locally or internationally. Additionally, it is recognised that inconsistent and low quality(More)
In this chapter, we discuss the parallelisation of three very popular random number generators. In each case, the random number sequence which is generated is identical to that produced on a CPU by the standard sequential algorithm. The key to the parallelisation is that each CUDA thread block generates a particular block of numbers within the original(More)
Epothilones are a new class of antimicrotubule agents currently in clinical trials. Their chemical structures are distinct from taxanes and are more amenable to synthetic modification. Six epothilones have been studied in preclinical and clinical trials: patupilone (epothilone B), ixabepilone (BMS247550), BMS 310705, sagopilone (ZK-EPO), KOS-862 (epothilone(More)
Adverse drug reactions (ADRs) are a major patient safety issue, and a substantial proportion of ADRs are, in fact, preventable. The aim of this study was to describe the proportion and pattern of preventable ADRs in spontaneously reported suspected ADRs and to study the feasibility of using data from an ADR reporting system for this purpose. All reports of(More)
The 28-percent change in average Medicare inpatient cost per case between 1984 and 1987 is decomposed into three components: input price inflation, changes in average cost within diagnosis-related groups (DRGs) (intensity), and changes in the distribution of cases across DRGs (case mix). We estimate the contributions of technology diffusion and outpatient(More)
Pregnancy in women with paroxysmal nocturnal hemoglobinuria (PNH) is associated with increased maternal and fetal morbidity and mortality. There is limited published experience regarding therapy of PNH during pregnancy. We describe a case of a 30 year old female with hypoplastic myelodysplastic syndrome and PNH. After two years of treatment with eculizumab,(More)
HIGH EFFICIENCY THERMOELECTRIC DEVICES FABRICATED USING QUANTUM WELL CONFINEMENT TECHNIQUES Experimental results are presented of thermoelectric materials, specifically two-dimensional quantum well confinement structures, formed by ion beam sputter deposition methods. Applications of these thermoelectric devices include nearly any system that generates heat(More)