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Phosphoinositide 3-kinase (PI3K) is deregulated in a wide variety of human tumors and triggers activation of protein kinase B (PKB/Akt) and mammalian target of rapamycin (mTOR). Here we describe the(More)
Mechanistic target of rapamycin (mTOR) promotes cell proliferation, growth and survival, and is overactivated in many tumors and central nervous system disorders. PQR620 (3) is a novel, potent,(More)