PURPOSE To evaluate the safety and efficacy of gadoxetic acid disodium-enhanced magnetic resonance (MR) imaging for the detection of focal liver lesions, with results of histopathologic examination and/or intraoperative ultrasonography used as a standard of reference. MATERIALS AND METHODS One hundred sixty-nine patients who were known to have or… (More)
KEY POINTS : The study by Stojanov et al does not convincingly support the conclusion that gadobutrol causes higher T1 enhancement in brain on unenhanced MRI. The study by Stojanov et al does not rule out confounding factors . The study by Stojanov et al has limitations in study design.
PURPOSE Contrast-enhanced magnetic resonance imaging (MRI) of the central nervous system (CNS) with gadolinium-based contrast agents (GBCAs) is standard of care for CNS imaging and diagnosis because of the visualization of lesions that cause blood-brain barrier breakdown. Gadobutrol is a macrocyclic GBCA with high concentration and high relaxivity. The… (More)
Objective: The aim of this study was to assess the potential risk of gadobutrol-enhanced magnetic resonance imaging (MRI) in patients with moderate to severe renal impairment for the development of nephrogenic systemic fibrosis (NSF). Materials and Methods: We performed a prospective, international, multicenter, open-label study in 55 centers. Patients with… (More)
Objective: The aim of this study was to provide a systematic safety analysis of gadobutrol after more than 29 million applications in clinical routine. Materials and Methods: Forty-two clinical development phase II to IV studies on gadobutrol or comparator and the postmarketing safety surveillance database for gadobutrol (1998–2015) were analyzed. Adverse… (More)
CITATION: Gutierrez et al. Correction to " Safety and Efficacy of Gadobutrol for contrast-enhanced Magnetic Resonance imaging of the central nervous system: Results from a Multicenter, Double-blind, Randomized, comparator study ". COPYRIGHT: © the authors, publisher and licensee Libertas academica Limited. this is an open-access article distributed under… (More)
The performance of a portfolio manager is in practice usually measured by the result of his trading strategy compared to a benchmark. Therefore the information whether there exists a strategy that allows to outperform the benchmark is of high value for an active investor. The article shows how this information can be generated in the binomial model. In this… (More)