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Two related pyrrolidinedione synthetase loci in Fusarium heterosporum ATCC 74349 produce divergent metabolites.

• Thomas B. Kakule, Debosmita Sardar, Zhenjian Lin, Eric W Schmidt
• ACS chemical biology
• 2013

Equisetin synthetase (EqiS), from the filamentous fungus Fusarium heterosporum ATCC 74349, was initially assigned on the basis of genetic knockout and expression analysis. Increasing inconsistencies… (More)

Combinatorialization of fungal polyketide synthase-peptide synthetase hybrid proteins.

• Thomas B. Kakule, Zhenjian Lin, Eric W Schmidt
• Journal of the American Chemical Society
• 2014

The programming of the fungal polyketide synthase (PKS) is quite complex, with a simple domain architecture leading to elaborate products. An additional level of complexity has been found within… (More)

Identification of Cyclic Depsipeptides and Their Dedicated Synthetase from Hapsidospora irregularis.

• Shuwei Zhang, Yixing Qiu, +10 authors Jixun Zhan
• Journal of natural products
• 2017

Seven cyclic depsipeptides were isolated from Hapsidospora irregularis and structurally characterized as the calcium channel blocker leualacin and six new analogues based on the NMR and HRESIMS data.… (More)

Biosynthesis of the tetramic acids Sch210971 and Sch210972.

• Thomas B. Kakule, Shuwei Zhang, Jixun Zhan, Eric W Schmidt
• Organic letters
• 2015

A biosynthetic pathway to fungal polyketide-nonribosomal peptide natural products, Sch210971 (1a) and Sch210972 (1b) from Hapsidospora irregularis, was characterized by reconstitution and… (More)

Native Promoter Strategy for High-Yielding Synthesis and Engineering of Fungal Secondary Metabolites

• Thomas B. Kakule, Raquel C. Jadulco, Michael Koch, Jeffrey E. Janso, Louis R Barrows, Eric W Schmidt
• ACS synthetic biology
• 2015

Strategies are needed for the robust production of cryptic, silenced, or engineered secondary metabolites in fungi. The filamentous fungus Fusarium heterosporum natively synthesizes the polyketide… (More)

Isolation of Pyrrolocins A–C: cis- and trans-Decalin Tetramic Acid Antibiotics from an Endophytic Fungal-Derived Pathway

• Raquel C. Jadulco, Michael Koch, +9 authors Louis R Barrows
• Journal of natural products
• 2014

Three new decalin-type tetramic acid analogues, pyrrolocins A (1), B (2), and C (3), were defined as products of a metabolic pathway from a fern endophyte, NRRL 50135, from Papua New Guinea. NRRL… (More)

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