Thomas Asbury

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Monitoring antigen-specific T cells is critical for the study of immune responses and development of biomarkers and immunotherapeutics. We developed a novel multiplex assay that combines conventional immune monitoring techniques and immune receptor repertoire sequencing to enable identification of T cells specific to large numbers of antigens(More)
A grossly cystic retinoblastoma, presumably a form of the diffuse infiltrating type, mimicked uveitis in an 81/2-year-old boy. A review of 44 cases indicated that grossly (clinically) detectably cysts are rare in this neoplasm, although microcysts are relatively common. Lesions of this nature, especially if presenting with a history of trauma, as in our(More)
OBJECTIVE Ankylosing spondylitis (AS), a chronic inflammatory disorder, has a notable association with HLA-B27. One hypothesis suggests that a common antigen that binds to HLA-B27 is important for AS disease pathogenesis. This study was undertaken to determine sequences and motifs that are shared among HLA-B27-positive AS patients, using T cell repertoire(More)
Using a notation system for evaluation of photocoagulatin of the choroidal neovascular membrane (CNVM) in presumed ocular histoplasmosis syndrome (POHS) demonstrated several advantages, which are: (1) a projector system which allowed excellent magnification of the CNVM and its distance from the foveal avascular zone (FAZ); (2) direct study of fluorescein(More)