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Chronic Wound Pathogenesis and Current Treatment Strategies: A Unifying Hypothesis
- Thomas A. Mustoe, MD, FACS, Kristina D. O'Shaughnessy, O. Kloeters
- MedicinePlastic and reconstructive surgery
- 1 June 2006
The authors propose a unifying hypothesis of chronic wound pathogenesis based on four main causative factors: local tissue hypoxia, bacterial colonization of the wound, repetitive ischemia-reperfusion injury, and an altered cellular and systemic stress response in the aged patient.
Understanding chronic wounds: a unifying hypothesis on their pathogenesis and implications for therapy.
- Thomas A. Mustoe, MD, FACS
- MedicineAmerican journal of surgery
- 1 May 2004
Oxygen in wound healing: More than a nutrient
An overview of the role of oxygen in wound healing and a synergistic effect of systemic hyperbaric oxygen and growth factors that has been substantiated by Hunt's group are provided.
Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms
- G. Pierce, Thomas A. Mustoe, MD, FACS, T. Deuel
- Medicine, BiologyThe Journal of cell biology
- 1 July 1989
In contrast, PDGF is a more potent chemoattractant for wound macrophages and fibroblasts and may stimulate these cells to express endogenous growth factors, including TGF-beta, which may stimulate new collagen synthesis and sustained enhancement of wound healing over a more prolonged period of time.
Factors influencing the use of breast reconstruction postmastectomy: a National Cancer Database study.
Acute and Chronic Animal Models for Excessive Dermal Scarring: Quantitative Studies
- D. Morris, L. Wu, Thomas A. Mustoe, MD, FACS
- Medicine, BiologyPlastic and reconstructive surgery
- 1 September 1997
An animal model for excessive dermal scarring that allows quantitation of scar formation and, at an early stage, can be modulated in a predictable way with intralesional corticosteroid treatment is presented.
Updated International Clinical Recommendations on Scar Management: Part 2—Algorithms for Scar Prevention and Treatment
- M. Gold, M. McGuire, Crystal Murcia
- MedicineDermatologic surgery : official publication for…
- 1 August 2014
Prevention and treatment of pathologic scarring requires individualized care built upon the principles of evidence-based medicine and continues to evolve in step with technological and scientific advances.
Hypertrophic scar model in the rabbit ear: a reproducible model for studying scar tissue behavior with new observations on silicone gel sheeting for scar reduction
- O. Kloeters, A. Tandara, Thomas A. Mustoe, MD, FACS
- Biology, MedicineWound repair and regeneration : official…
- 1 September 2007
The HS model in the rabbit ear is a highly reliable, responsive, and practical model for studying scar tissue behavior and it is suggested that the degree and the duration of occlusion are most important for reducing scar tissue formation.
In vivo modeling of biofilm-infected wounds: a review.
Role of platelet‐derived growth factor in wound healing
- G. Pierce, Thomas A. Mustoe, MD, FACS, B. Altrock, T. Deuel, A. Thomason
- Medicine, BiologyJournal of cellular biochemistry
- 1 April 1991
PDGF appears to transduce its signal through wound macrophages and may trigger the induction of positive autocrine feedback loops and synthesis of endogenous wound PDGF and other growth factors, thereby enhancing the cascade of tissue repair processes required for a fully‐healed wound.