Thomas A. Walker

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The adenoviral E1A oncogene sensitizes mammalian cells to tumor necrosis factor-alpha (TNF-alpha), in part by repressing the nuclear factor-kappa B (NF-kappa B)-dependent defense against this cytokine. Other E1A activities involve binding to either p300/cyclic AMP response element-binding protein (CBP) or retinoblastoma (Rb)-family proteins, but the roles(More)
Huntington's disease (HD) is caused by the expansion of a CAG repeat in the huntingtin (HTT) gene. The R6 mouse models of HD express a mutant version of exon 1 HTT and typically develop motor and cognitive impairments, a widespread huntingtin (HTT) aggregate pathology and brain atrophy. Unlike the more commonly used R6/2 mouse line, R6/1 mice have fewer CAG(More)
Partial search has been proposed recently for finding the target block containing a target element with fewer queries than the full Grover search algorithm which can locate the target precisely. Since such partial searches will likely be used as sub-routines for larger algorithms their success rate is important. We propose a partial search algorithm which(More)
In this article we outline a method for generating linear optics circuits that encode quantum-error-correcting codes. Using this method we produce a single-error-correcting code encoding one wave packet over five which can be implemented using linear optics and feed-forward correction. This code improves on the capacity of the best known code that can be(More)
Despite regulation, brain iron increases with aging and may enhance aging processes including neuroinflammation. Increases in magnetic resonance imaging transverse relaxation rates, R2 and R2*, in the brain have been observed during aging. We show R2 and R2* correlate well with iron content via direct correlation to semi-quantitative synchrotron-based X-ray(More)
A variety of mouse models have been developed that express mutant huntingtin (mHTT) leading to aggregates and inclusions that model the molecular pathology observed in Huntington's disease. Here we show that although homozygous HdhQ150 knock-in mice developed motor impairments (rotarod, locomotor activity, grip strength) by 36 weeks of age, cognitive(More)
Quantum error-correcting codes can protect multipartite quantum states from errors on some limited number of their subsystems (usually qubits). We construct a family of Bell inequalities which inherit this property from the underlying code and exhibit the violation of local realism, without any quantum information processing (except for the creation of an(More)
We quantify the resolution with which any probability distribution may be distinguished from a displaced copy of itself in terms of a characteristic width. This width, which we call the resolution, is well defined for any normalizable probability distribution. We use this concept to study the broadcasting of classical probability distributions. Ideal(More)
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