Thomas A. Kriz

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The Mdm2 ubiquitin ligase is an important regulator of p53 abundance and p53-dependent apoptosis. Mdm2 expression is frequently regulated by a p53 Mdm2 autoregulatory loop whereby p53 stimulates Mdm2 expression and hence its own degradation. Although extensively studied in cell lines, relatively little is known about Mdm2 expression in heart where oxidative(More)
Cardiac surgery occurs at a tremendous volume worldwide and the number of cardiac surgical procedures is steadily increasing every year. Demographic change, technological advance and the growing burden of chronic disease mean that this trend is set to continue, placing further demand on limited healthcare resources. Complex interventions can be described as(More)