Thom Maughan

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This randomised, double-blind, placebo-controlled study was designed to evaluate the ability of the orally administered matrix metalloproteinase inhibitor, marimastat, to prolong survival in patients with non-resectable gastric and gastro-oesophageal adenocarcinoma. Three hundred and sixty-nine patients with histological proof of adenocarcinoma, who had(More)
PURPOSE We conducted a retrospective analysis to evaluate the safety and efficacy of Campath-1H, an anti-CD52 humanized monoclonal antibody, in previously treated T-prolymphocytic leukemia (T-PLL) patients in a compassionate-use program. PATIENTS AND METHODS Seventy-six patients with T-PLL (including four chemotherapy-naive patients) received 3, 10, and(More)
In this paper we describe an integrated goal-oriented control architecture for onboard decision-making for AUVs. Onboard planning and execution is augmented by state estimation of perceived features of interest in the coastal ocean, to drive platform adaptation. The partitioned architecture is a collection of coordinated control loops, with a recurring(More)
With the advent of Autonomous Underwater Vehicles (AUVs) and other mobile platforms, marine robotics have had substantial impact on the oceanographic sciences. These systems have allowed scientists to collect data over temporal and spatial scales that would be logistically impossible or prohibitively expensive using traditional ship-based measurement(More)
We have designed, built, tested and fielded a decision support system which provides a platform for situational awareness, planning, observation, archiving and data analysis. While still in development, our inter-disciplinary team of computer scientists, engineers, biologists and oceanographers has made extensive use of our system in at-sea experiments(More)
This open-label, non-randomized, parallel-group trial investigated the pharmacokinetics of raltitrexed (Tomudex, formerly ZD1694) after a single intravenous dose of 3.0 mg m(-2), comparing eight cancer patients with mild to moderate renal impairment (creatinine clearance 25-65 ml min(-1)) with eight cancer patients with normal renal function (creatinine(More)
We present AUV survey methodologies to track and sample an advecting patch of water. Current AUV-based sampling rely primarily on geographic waypoint track-line surveys that are suitable for static or slowly changing features. When studying dynamic, rapidly evolving oceanographic features, such methods at best introduce error through insufficient spatial(More)