Thom LaBean

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Libraries of random sequence polypeptides are useful as sources of unevolved proteins, novel ligands, and potential lead compounds for the development of vaccines and therapeutics. The expression of small random peptides has been achieved previously using DNA synthesized with equimolar mixtures of nucleotides. For many potential uses of random polypeptide(More)
While algorithmic DNA self-assembly in theory is capable of forming complex patterns , its experimental demonstration has been limited by significant assembly errors. Activatable DNA tiles employ a protection/deprotection strategy to strictly enforce the direction of tiling assembly growth to ensure the robustness of the assembly process. Tiles are(More)
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