Thodor M. Vasudevan

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Abdominal aortic aneurysm (AAA) is a common human disease with a high estimated heritability (0.7); however, only a small number of associated genetic loci have been reported to date. In contrast, over 100 loci have now been reproducibly associated with either blood lipid profile and/or coronary artery disease (CAD) (both risk factors for AAA) in(More)
BACKGROUND Intracranial aneurysms (IAs), abdominal aortic aneurysms (AAAs), and thoracic aortic aneurysms (TAAs) all have a familial predisposition. Given that aneurysm types are known to co-occur, we hypothesized that there may be shared genetic risk factors for IAs, AAAs, and TAAs. METHODS AND RESULTS We performed a mega-analysis of 1000 Genomes(More)
S. Carrell23, Glenn S. Gerhard24, David P. Franklin25, David J. Carey2, Victoria L. Phillips1, Michael J. A. Williams26, Wenhua Wei1, Ross Blair27, Andrew A. Hill28, Thodor M. Vasudevan27, David R. Lewis29, Ian Thomson1, Jo Krysa1, Geraldine B. Hill1, Justin Roake29, Tony R. Merriman30, Grzegorz Oszkinis8, Silvia Galora6, Claudia Saracini6, Rosanna Abbate6,(More)
RATIONALE Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA. OBJECTIVE To identify additional AAA risk loci using data from all available genome-wide association studies. METHODS AND RESULTS Through(More)
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