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Journals and Conferences
Amyloidogenesis has been implicated in a broad spectrum of diseases in which amyloid protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one of the most devastating ailments among amyloidogenesis induced dementia. The amyloid beta (Aβ) peptide derived from amyloid precursor protein (APP) is misfolded and deposited as… (More)
A new highly selective colorimetric chemosensor for Co(2+) was developed based on coumarin-conjugated thiocarbanohydrazone. The ligand senses Co(2+) in solution by changing its color from light yellow to deep pink. The sensor has been used in the development of practically viable colorimetric kits and as a staining agent for Co(2+) in microorganisms.
Accumulation of amyloid beta (Aβ) peptide and its aggregates in the human brain is considered as one of the hallmarks of Alzheimer's disease (AD). The polymorphic oligomers and fully grown fibrillar aggregates of Aβ exhibit different levels of neuronal toxicity. Moreover, aggregation of Aβ in the presence of redox-active metal ions like Cu(2+) is… (More)
Alkyne-modified biomolecules can be immobilized site- and chemoselectively on sulfonylazide slides under very mild conditions by means of the click sulfonamide reaction.
Alzheimer's disease is one of the devastating illnesses mankind is facing in the 21st century. The main pathogenic event in Alzheimer's disease is believed to be the aggregation of the β-amyloid (Aβ) peptides into toxic aggregates. Molecules that interfere with this process may act as therapeutic agents for the treatment of the disease. Use of recognition… (More)
A conformationally constrained (coumarin-pyrrolidinyl-triazolyl-bipyridyl) fluoroionophore conjugate was synthesized through click chemistry. The fluoroionophore serves as a selective chemosensor for Al(3+) based on internal charge transfer. The coumarin-bipyridyl chemosensor exhibited a high association constant with submicromolar detection for the… (More)
A novel quinoline-coumarin (QC) fluoroionophore conjugated by means of a triazolyl-pyrrolidinyl linker exhibits differential dual selectivity for Zn(2+) and Al(3+) in mixed media. QC acts as a turn on fluorescence sensor for Zn(2+) while exhibiting overall ratiometric selectivity for Al(3+) in aqueous media. Moreover, QC exhibited preferential second mode… (More)
A pyrrolidine constrained bipyridyl-dansyl (ionophore-fluorophore) conjugate with triazole linker was synthesised through click chemistry. The fluoroionophore serves as a selective ratiometric and colorimetric chemosensor for Al(3+) based on internal charge transfer (ICT).
Sequence-specific recognition of DNA by small turn-on fluorescence probes is a promising tool for bioimaging, bioanalytical and biomedical applications. Here, the authors report a novel cell-permeable and red fluorescent hemicyanine-based thiazole coumarin (TC) probe for DNA recognition, nuclear staining and cell cycle analysis. TC exhibited strong… (More)