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  • Thierry Lavé, Sylvie Dupin, Claus Peter Schmitt, Robert Chou, Daniel Jaeck, Philippe Coassolo
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • 1997 (First Publication: 1 May 1997)
  • In this study, we investigated rational and reliable methods of using animal data to predict in humans the clearance of drugs which are mainly eliminated through hepatic metabolism. For 10Continue Reading
  • Agnès Poirier, Thierry Lavé, +5 authors Christoph Funk
  • Chemistry, Medicine
  • Drug Metabolism and Disposition
  • 2008 (First Publication: 1 December 2008)
  • The use of in vitro data for quantitative predictions of transporter-mediated elimination in vivo requires an accurate estimation of the transporter Michaelis-Menten parameters, Vmax and Km, as aContinue Reading
  • Olivier Luttringer, F P Theil, Thierry Lavé, Karin Wernli-Kuratli, Theodor W. Guentert, Antoine B de Saizieu
  • Chemistry, Medicine
  • Biochemical pharmacology
  • 2002 (First Publication: 1 December 2002)
  • The influence of the isolation procedure of hepatocytes, extracellular matrix (ECM) configuration and incubation medium supplementation by dexamethasone (DEX) on the cell morphology and on the geneContinue Reading
  • Patrick Poulin, Rhys D O Jones, +15 authors James W. T. Yates
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • 2011 (First Publication: 1 October 2011)
  • The objective of this study is to assess the effectiveness of physiologically based pharmacokinetic (PBPK) models for simulating human plasma concentration-time profiles for the unique drug datasetContinue Reading
  • Rhys D O Jones, Hannah M. Jones, +15 authors Patrick Poulin
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • 2011 (First Publication: 1 October 2011)
  • The objective of this study was to evaluate the performance of various empirical, semimechanistic and mechanistic methodologies with and without protein binding corrections for the prediction ofContinue Reading
  • Neil John Parrott, Nicolas Paquereau, Philippe Coassolo, Thierry Lavé
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • 2005 (First Publication: 1 October 2005)
  • Generic physiologically-based models of pharmacokinetics were evaluated for early drug discovery. Plasma profiles after intravenous and oral dosing were simulated in rat for 68 compounds from sixContinue Reading
  • Agnès Poirier, Anne-Christine Cascais, Christoph Funk, Thierry Lavé
  • Medicine, Chemistry
  • Journal of Pharmacokinetics and Pharmacodynamics
  • 2009 (First Publication: 1 December 2009)
  • The aim of this study was to evaluate a strategy based on a physiologically based pharmacokinetic (PBPK) model for the prediction of PK profiles in human using in vitro data when elimination ofContinue Reading