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Autophagy (macroautophagy) is a degradative process that involves the sequestration of cytosolic material including organelles into double membrane vesicles termed autophagosomes for delivery to the lysosome. Autophagy is essential for preimplantation development of mouse embryos and cavitation of embryoid bodies. The precise roles of autophagy during early(More)
Analysing tissue and gene function in intestinal organ culture. Ventilation of the very immature lung in utero induces injury and BPD-like changes in lung structure in fetal sheep. Maternal dietary supplementation with saturated, but not mono-unsaturated or poly-unsaturated fatty acids leads to tissue specific inhibition of offspring Na/K ATPase.(More)
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