Thien Tra

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Burkholderia pseudomallei is the causative agent of melioidosis, a tropical infection of humans and other animals. The bacterium is an intracellular pathogen that can escape from endosomes into the host cytoplasm, where it replicates and infects adjacent cells. We investigated the role played by autophagy in the intracellular survival of B. pseudomallei in(More)
Autophagy (macroautophagy) is a degradative process that involves the sequestration of cytosolic material including organelles into double membrane vesicles termed autophagosomes for delivery to the lysosome. Autophagy is essential for preimplantation development of mouse embryos and cavitation of embryoid bodies. The precise roles of autophagy during early(More)
Analysing tissue and gene function in intestinal organ culture. Ventilation of the very immature lung in utero induces injury and BPD-like changes in lung structure in fetal sheep. Maternal dietary supplementation with saturated, but not mono-unsaturated or poly-unsaturated fatty acids leads to tissue specific inhibition of offspring Na/K ATPase.(More)
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