Thibault Comont

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INTRODUCTION Hepatitis E virus (HEV) infection is now recognized to be an emerging autochthonous disease in several countries. There have been several reports of neurological manifestations associated with HEV infections. Immunocompromised patients seem to be particularly vulnerable. CASE REPORT We report a 73-year-old man who presented with an acute(More)
BACKGROUND Vinblastine is the standard treatment for children with Langerhans cell histiocytosis (LCH). Whether this treatment could be extended to adults with LCH is questionable. This retrospective multicenter study included 35 adult patients (median age 33 years; 23 men; 80% with multisystem LCH) who were treated with vinblastine + steroids as a(More)
Dear Editor, Haemophagocytic lymphohistiocytosis (HLH) may be triggered by various infectious or non-infectious conditions (1). HLH has rarely been associated with visceral leishmaniasis (VL) (2), and as far as we know, never with a sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman (RD) disease (3)). We report a case of life-threatening HLH(More)
Platelet transfusion refractoriness (PTR) is a major adverse event in the management of acute myeloid leukemia (AML). In a series of 897 adult patients with AML receiving intensive chemotherapy, we identified 41 patients (4.8%) with PTR. PTR was more frequently observed in parous women, patients with extra-medullary disease, a low white blood cell count, an(More)
The clinical epidemiology of immune thrombocytopenia (ITP) is not well known in adults. This study was aimed at assessing the clinical epidemiology of incident ITP adults, the factors associated with chronicity and exposure to treatments. This study was conducted in the CARMEN registry, a multicentric prospective cohort aimed at including all newly(More)
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