Thiago de Sousa Melo

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The objective of this study was to estimate the requirements for maintenance and gain of crude protein in Japanese and European quails aged 16-36 days. To determine the maintenance requirements, one experiment was conducted in a completely randomized design with four decreasing feeding levels (100, 75, 50 and 25%) and four replicates per treatment. The(More)
We study the Reidemeister torsion and the analytic torsion of the m dimensional disc in the Euclidean m dimensional space, using the base for the homology defined by Ray and Singer in [20]. We prove that the Reidemeister torsion coincides with a power of the volume of the disc. We study the additional terms arising in the analytic torsion due to the(More)
We provide a simple topological derivation of a formula for the Reidemeister and the analytic torsion of spheres. Weng and You gave in [6] a formula for the analytic torsion of a sphere with the standard metric. Their result is obtained by direct calculation applying the definition of analytic torsion, and is based on the explicit knowledge of the spectrum(More)
5-methoxypsoralen (5-MOP) binds to human serum low density lipoproteins (LDL) according to a two-step process. Scatchard analysis of the first step yields K = 1.4 X 10(5) M-1 and 4 binding sites. It involves the LDL apoprotein. The second step corresponds to a solubilization, in the lipidic core, of congruent to 45 molecules of 5MOP per LDL molecule. It is(More)
The phototoxic effect of psoralen (PSO), 5-methoxypsoralen (5MOP), 8-methoxypsoralen (8MOP) and 4,5',8-trimetylpsoralen (TMP) has been compared on the NCTC 2544 keratinocyte cell line in terms of cell mortality and lipid peroxidation. The order of effectiveness for cell photokilling is TMP, 5MOP >> 8MOP, PSO, whereas a little lipid peroxidation is observed(More)
The physico-chemical properties and the stability of anthralin, a potent antipsoriatic agent, has been investigated in model systems by optical absorption and fluorescence spectroscopy and by gas chromatography coupled to mass spectrometry. Systematic studies were carried out on anthralin and its oxidation products (1,8-dihydroxyanthraquinone and(More)
Pretreatment of EMT-6 murine tumor cells for 24 h with 10(-4) M 8-methoxypsoralen (8-MOP) increased the photocytotoxicity of Photofrin II (P2) after cell exposure to low doses (1-1.5 J/cm2) of UVA by two- to three-fold. 8-MOP alone had no cytotoxic action under these experimental conditions and did not significantly change the amount of P2 recovered in(More)
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