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Can macroalgae provide promising anti-tumoral compounds? A closer look at Cystoseira tamariscifolia as a source for antioxidant and anti-hepatocarcinoma compounds
TLDR
Demethoxy cystoketal chromane, a derivative of the meroditerpenoid cystketal, was identified as the active compound in CTH and was shown to display selective in vitro cytotoxicity towards HepG2 cells. Expand
Anti-malarial, anti-trypanosomal, and anti-leishmanial activities of jacaranone isolated from Pentacalia desiderabilis (Vell.) Cuatrec. (Asteraceae)
TLDR
Results suggested that jacaranone, as other similar secondary metabolites or synthetic analogs, might be useful tolls for drug design for in vivo studies against protozoan diseases. Expand
Antiparasitic Activity of Natural and Semi-Synthetic Tirucallane Triterpenoids from Schinus terebinthifolius (Anacardiaceae): Structure/Activity Relationships
TLDR
The in vitro antiparasitic activity and mammalian cytotoxicity of three natural tirucallane triterpenoids, isolated from leaves of Schinus terebinthifolius (Anacardiaceae), and nine semi-synthetic derivatives were investigated against Leishmania (L.) infantum and Trypanosoma cruzi. Expand
Antiparasitic activity of piplartine (piperlongumine) in a mouse model of schistosomiasis.
TLDR
In vivo antischistosomal properties of isolated piplartine were evaluated in a mouse model of schistosomiasis infected with either adult or juvenile stages of Schistosoma mansoni and indicated that this bioactive molecule derived from medicinal plants could be a potential lead compound for novel antischistingosomal agents. Expand
Promethazine Exhibits Antiparasitic Properties In Vitro and Reduces Worm Burden, Egg Production, Hepatomegaly, and Splenomegaly in a Schistosomiasis Animal Model
TLDR
Considering the importance of the repositioning of drugs in infectious diseases, especially those related to poverty, the evaluation of the efficacy of promethazine against Schistosoma mansoni ex vivo and in a murine model of schistosomiasis revealed the possibility ofpromethazine repositioned as an antischistosomal agent. Expand
Cystoseira algae (Fucaceae): update on their chemical entities and biological activities
Abstract Cystoseira (Sargassaceae) is a genus of marine brown algae composed of about 40 species, which is distributed along the Eastern Atlantic and Mediterranean coasts. The biological potential ofExpand
Antileishmanial activity of meroditerpenoids from the macroalgae Cystoseira baccata.
TLDR
This work identified compound 2 as a novel metabolite and compound 1 as a biochemical isolated from Cystoseira algae displaying antileishmanial activity as an interesting scaffold for the development of novel chemotherapeutic molecules for canine and human visceral leishmaniases studies. Expand
H1-antihistamines as antischistosomal drugs: in vitro and in vivo studies
TLDR
Treatment with any of the three antihistamines is more effective in early infection than praziquantel, and the clinical use of H1-antihistamines for the treatment of schistosomiasis is highly unlikely. Expand
Incorporation of polygodial in Langmuir films of selected lipids
Abstract Identification of membrane sites capable of drug binding is important to understand the interaction of bioactive compounds with biointerfaces such as microbial cellular membranes. As theExpand
Application of an Ionic Liquid in the Microwave Assisted Extraction of Cytotoxic Metabolites from Fruits of Schinus terebinthifolius Raddi (Anacardiaceae)
This work reports the application of an ionic liquid (1-butyl-3-methylimidazolium bromide, BMImBr) in the microwave assisted extraction (MAE) of metabolites from fruits of Schinus terebinthifolius.Expand
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