Thiagarajan Krishnamurthy

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A recently developed Centroidal Voronoi Tessellation (CVT) sampling method is investigated here to assess its suitability for use in response surface generation. CVT is an unstructured sampling method that can generate nearly uniform point spacing over arbitrarily shaped Mdimensional parameter spaces. For rectangular parameter spaces (hypercubes), CVT(More)
A radial basis function implementation of the meshless local Petrov-Galerkin (MLPG) method is presented to study Euler-Bernoulli beam problems. Radial basis functions, rather than generalized moving least squares (GMLS) interpolations, are used to develop the trial functions. This choice yields a computationally simpler method as fewer matrix inversions and(More)
Administration of morphine by the oral route is not possible in cancer patients who are unable to swallow or are intolerant of oral morphine. Thus, there is a need for reliable alternate routes of drug administration. We compared the bioavailability of two prototype 30-mg morphine sulfate controlled-release suppository formulations (high and low viscosity)(More)
Response surface functions are often used as simple and inexpensive replacements for computationally expensive computer models that simulate the behavior of a complex system over some parameter space. “Progressive” response surfaces are ones that are built up progressively as global information is added from new sample points in the parameter space. As the(More)
Studies on the relative effects of parents on some economic characters in sugarcane have given indications of maternal influence in the progeny performance in certain crosses with regard to millable canes at harvest, height of stalks and brix per cent in juice, irrespective of the fact that pollen parent effect was positive or negative. As judged from a(More)
Response surface functions are often used as simple and inexpensive replacements for computationally expensive computer models that simulate the behavior of a complex system over some parameter space. "Progressive" response surfaces are built up incrementally as global information is added from new sample points added to the previous points in the parameter(More)
Availability of analytical method which is compatible with both Ultra high performance liquid chromatography (UHPLC) and Liquid chromatography mass spectrometry to identify and quantify the impurities in pharmaceutical products is an advantage for drug product development; such analytical method was developed for Nimesulide using a fused core column.(More)
In modern era, Ultra low power design has an Active research topic due to its various Applications. In this paper we introduce a novel low power and Area efficient Binary to Gray code converter is implemented by using two transistor XOR gate. This two Transistor XOR gate is designed by using two PMOS transistors. Both two transistor and Binary to Gray code(More)
A polysaccharide, isolated from rapeseed hulls by extraction with aqueous sodium hydroxide-sodium tetraborate, contained residues of L-arabinose, L-fucose, D-xylose, D-galactose, and D-glucose in the proportions of 2:8:25:13:52. Acetolysis furnished cellobiose, 6-O-alpha-D-xylopyranosyl-D-glucose, and 2-O-beta-D-galactopyranosyl D-xylose. The cleavage(More)