Thi-Ngoc-Phuong Huynh

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A series of simple heterocyclic chalcone analogues have been synthesized by Claisen Schmidt condensation reactions between substituted benzaldehydes and heteroaryl methyl ketones and evaluated for their antibacterial activity. The structures of the synthesized chalcones were established by IR and ¹H-NMR analysis. The biological data shows that compounds p₅,(More)
Benzo[c]phenanthridine (BCP) derivatives were identified as topoisomerase I (TOP-I) targeting agents with pronounced antitumor activity. In this study, hologram-QSAR, 2D-QSAR and 3D-QSAR models were developed for BCPs on topoisomerase I inbibitory activity and cytotoxicity against seven tumor cell lines including RPMI8402, CPT-K5, P388, CPT45, KB3-1,(More)
Benzo[c]phenanthridine (BCP) derivatives were identified as topoisomerase I (TOP-I) targeting agents with pronounced antitumor activity. In this study, a support vector machine model was performed on a series of 73 analogues to classify BCP derivatives according to TOP-I inhibitory activity. The best SVM model with total accuracy of 93% for training set was(More)
Figure S1. Process of 2D-QSAR in Rapidminer software Table S1. Dataset of 133 BCPs compounds with their cytotoxicity on RPMI8402 cell line: experimental pIC 50 value and predictive results Table S2. Dataset of 101 BCPs compounds with their cytotoxicity on CPTK5 cell line: experimental pIC 50 value and predictive results Table S3. Dataset of 82 BCPs(More)
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