Theresia Hummel

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OBJECTIVES Despite considerable progress in intensive care management of the acute respiratory distress syndrome (ARDS), little is known about health-related quality of life in long-term survivors. In addition, intensive care treatment can be extremely stressful, and many survivors of ARDS report adverse experiences such as respiratory distress, anxiety, or(More)
OBJECTIVE To investigate the effects of stress doses of hydrocortisone on the duration of vasopressor therapy in human septic shock. DESIGN Prospective, randomized, double-blind, single-center study. SETTING Twenty-bed multidisciplinary intensive care unit in a 1400-bed university hospital. PATIENTS Forty consecutive patients who met the ACCP/SCCM(More)
Objective: We performed a follow-up cohort analysis in order to delineate the correlation between pulmonary function (PF) and health-related quality of life (HRQL) in patients after ARDS.¶Design: Follow-up cohort study.¶Setting: A 20-bed ICU of a university teaching hospital.¶Patients: A cohort of 50 long-term survivors of ARDS.¶Measurements and results:(More)
UNLABELLED Treatment of severe acute respiratory distress syndrome (ARDS) with extracorporeal membrane oxygenation (ECMO) can be lifesaving but requires maximal use of intensive care resources over prolonged periods of time, resulting in high costs. Little is known about the health-related quality of life (HRQL) in long-term survivors. This case-controlled(More)
Production of oxygen radicals is required for both microbicidal and tissue-toxic effector functions of granulocytes. Inasmuch as an ambivalent role of polymorphonuclear leukocytes (PMNs) may become apparent during sepsis, we studied levels of hydrogen peroxide (H2O2) production by PMNs depending upon the nature of different particulate and soluble stimuli(More)
Inasmuch as polymorphonuclear leukocytes (PMNs) play a major role in antibacterial defense but can also cause substantial tissue injury, drugs are needed which are able to attenuate tissue-toxic PMN reactions without inhibiting bactericidal mechanisms. Adenosine as a retaliatory metabolite is produced in response to metabolically unfavorable conditions like(More)
Die Letalität des ARDS ist nach wie vor hoch. Um den Stellenwert der ECMO als zusätzliche Behandlungsoption zur konventionellen Beatmungstherapie zu untersuchen, wurden 60 Patienten mit schwerem ARDS prospektiv evaluiert. 39 Patienten wurden konventionell behandelt, weil sich ihr pulmonaler Gasaustausch besserte (n=37) oder Kontraindikationen gegen ECMO(More)
Extracorporeal membrane oxygenation is a suitable technique for short-term treatment of resistant respiratory failure with a comparably low mortality rate of 32%. However, pulmonary complications are quite often encountered during ECMO therapy making thoracic interventions necessary. The most frequent of these complications is hemorrhage followed by lung(More)
Einführung und Methodik: Die extrakorporale Membranoxigenation (ECMO) zur Behandlung des schweren ARDS beim Erwachsenen ist eine aufwendige und teure Methode und in Einzelfällen lebensrettend. Es existieren jedoch keine Daten zur gesundheitsbezogenen Lebensqualität (HRQL) von langzeitüberlebenden Patienten nach ECMO-Behandlung. Wir untersuchten daher 14(More)
To assess the effects of stress doses of hydrocortisone (HC) on clinical parameters and neutrophil functions in patients with septic shock. Prospective, double-blind, randomized, placebo-controlled study. Intensive care units of a university hospital. 30 adult patients with septic shock. Patients were allocated to receive either HC (intravenous bolus of 100(More)