Therese Healy

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The effect of ketamine on sympathetic ganglion transmission has been studied using the guineapig isolated hypogastric nerve-vas deferens preparation. Ketamine produced a dose-dependent depression in the response to preganglionic stimulation (IC50 2.05 X 10--4 mol litre--1). No change in the response to postganglionic stimulation was recorded. The(More)
The neuromuscular blocking action of atracurium and vecuronium acting separately and in combination have been compared using the evoked EMG of the adductor pollicis muscle. Dose response curves have been drawn for the drugs given separately and found to be nonparallel (P less than 0.05). Atracurium was calculated to be 5.25 and 4.1 times less potent than(More)
The effects of atracurium and alcuronium on the evoked mechanical and electromyographic responses of the adductor pollicis were investigated in 30 adult patients. The ulnar nerve was stimulated with trains of four supramaximal pulses of 0.2 ms duration and a frequency of 2 Hz at intervals of 20 s. The mechanical response was measured using a strain gauge(More)
Two instruments measuring evoked compound muscle action potentials (EMG) produced by train of four stimulation of the ulnar nerve were compared. The neuromuscular transmission section of a Datex Anaesthesia and Brain Monitor (ABM), which utilises an integration technique to measure the EMG, and the Medelec MS6 , by which amplitude of the EMG was recorded(More)
The effects of neuromuscular blockade by atracurium and vecuronium on the power spectrum of the evoked compound action potential (ECAP) of the adductor pollicis were investigated in 30 adult patients undergoing elective surgery. The changes in amplitude and mean power frequency (MPF) of the ECAP were measured. Ten patients received an ED95 (0.23 mg kg-1) of(More)
The effect of atracurium or vecuronium on the depolarization phase of the evoked compound action potential of the adductor pollicis has been investigated in 30 adult patients. Patients were studied using single supramaximal stimulation of the ulnar nerve at the wrist. The evoked compound action potential was measured over the adductor pollicis muscle. When(More)
Twenty-two anaesthetists participated in a study to assess the influence of occupational exposure to anaesthetic agents on mood (arousal and stress) and cognitive functions. In a cross-over design, each anaesthetist worked one day in a reference facility (for example, intensive care) and another day in a scavenged operating theatre where time-weighted(More)
We have compared intubating conditions at 60 seconds, onset times and reversal characteristics of the new steroidal nondepolarizing muscle relaxant rocuronium with atracurium and vecuronium. A dose of approximately 1.75 X ED90 of each agent was used to assess their relative suitability for brief day case dental procedures requiring intubation. The(More)