Theresa S Chu

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OBJECTIVE To identify the presence of side population (SP) cells in established head and neck squamous carcinoma cell (HNSCC) lines and to determine the role of EGFR in the regulation of the side population of these cells. METHODS SP cells were identified using flow cytometry analysis by the ability of these cells to extrude the Hoechst 33342 dye via the(More)
OBJECTIVE The objective of this study was to determine whether STI-571 (Gleevec; imatinib mesylate) could sensitize established head and neck squamous cell carcinoma (HNSCC) cell lines to the effects of cisplatin. METHODS Western blot analysis and immunofluorescence were used to examine the expression of the tyrosine kinases that are known targets of(More)
OBJECTIVES The objectives of this study were to determine the effects of Gleevec on p63 expression in head and neck squamous cell carcinoma (HNSCC) cell lines and to investigate the role of Gleevec in regulating p63 stabilization under DNA-damaging conditions. METHODS Immunohistochemical staining was performed to determine p63 expression in HNSCC tissue.(More)
OBJECTIVE To investigate whether the mechanism for the reversal of ABCG2 (also known as ABCP, MXR, and BCRP)-mediated drug resistance by imatinib mesylate (Gleevec, STI571; Novartis Pharmaceuticals Corp, East Hanover, New Jersey) is caused by the downregulation of Akt kinase. The adenosine triphosphatase-binding cassette protein ABCG2 has been suggested to(More)
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