Theresa Frank

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Some herpesviruses like human cytomegalovirus (HCMV) encode viral G protein-coupled receptors that cause reprogramming of cell signaling to facilitate dissemination of the virus, prevent immune surveillance and establish life-long latency. Human GPCRs are known to function in complex signaling networks involving direct physical interactions as well as(More)
Silicibacter sp. TM1040 is a member of the Roseobacter clade. Roseobacters play an important role in sulfur cycling in the ocean by degrading dimethylsulfoniopropionate (DMSP). Roseobacters are found in communities associated with most marine habits, especially with marine algae. Therefore, the ability to sense, move towards and maintain the interaction is(More)
In this work we report a design, synthesis, and detailed functional characterization of unique strongly biased allosteric agonists of CXCR3 that contain tetrahydroisoquinoline carboxamide cores. Compound 11 (FAUC1036) is the first strongly biased allosteric agonist of CXCR3 that selectively induces weak chemotaxis and leads to receptor internalization and(More)
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