Theodore S. Cochrane

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There is circumstantial evidence implicating hypoglycaemia in the sudden overnight death of young patients with insulin-dependent (Type 1) diabetes mellitus (IDDM), the mechanism of which is unknown. We have investigated the effects of hypoglycaemia on the electrocardiogram in 15 patients with diabetes (8 with IDDM and 7 with NIDDM) using a high resolution(More)
Hypoglycaemia is the most common complication affecting people with Type 1 insulin dependent diabetes mellitus. Its onset is characterized by symptoms which include sweating, tremor, palpitations, loss of concentration and tiredness. As part of a research project to investigate the mechanisms of hypoglycaemia we have developed an ambulatory system to(More)
Orifice areas calculated by the continuity and Gorlin equations have been shown to correlate well in vivo. The continuity equation, however, gives underestimates compared with the Gorlin formula and it is not clear which is the more accurate. Both equations have therefore been tested against maximal orifice area measured by planimetry in eight prepared(More)
Diabetic neuropathic ulcers typically occur at high pressure sites. Microvascular blood flow has been assessed on the plantar surface of the foot in three matched groups each of 12 subjects free from macrovascular disease: (a) patients with diabetic neuropathy with abnormal foot pressures and previous neuropathic ulceration; (b) non-neuropathic diabetic(More)
Because aortic stenosis results in the loss of left ventricular stroke work (due to resistance to flow through the valve and turbulence in the aorta), the percentage of stroke work that is lost may reflect the severity of stenosis. This index can be calculated from pressure data alone. The relation between percent stroke work loss and anatomic aortic valve(More)
This paper describes an extension of the Windkessel model of circulatory system dynamics, which takes into account the opening action of the mitral and aortic valves, including stenotic and regurgitant orifices. The starting point for the model is the ventricular emptying/filling curve which is taken from a quasi-physiological ventricular flow relationship(More)
A computer simulation model of cardiac rhythm disturbances and of the heart/pacemaker interaction has been created and implemented on a NORD-100 minicomputer. The model incorporates important properties including cycle length dependence of the refractory periods of different parts of the heart and of the atrioventricular nodal conduction speed.(More)
A discrete computer model simulating the operation of the cardiac impulse transmission apparatus and the electropotential changes of the heart musculature has been developed on a NORD-100 minicomputer. The model is written in NORD-FORTRAN and allows description of practically all basic pathologies of the transmission apparatus. A simulated ECG curve is(More)