Theodore R Sadler

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To evaluate functional neuronal compensation after partial damage to the nigrostriatal system, we lesioned rats unilaterally in the striatum with 6-hydroxydopamine. Five weeks later, cerebral perfusion was mapped at rest or during treadmill walking using [(14)C]-iodoantipyrine. Regional CBF-related tissue radioactivity (CBF-TR) was quantified by(More)
Conditioned fear (CF) is one of the most frequently used behavioral paradigms; however, little work has mapped changes in cerebral perfusion during CF in the rat-the species which has dominated CF research. Adult rats carrying an implanted minipump were exposed to a tone (controls, n = 8) or a tone conditioned in association with footshocks (CS group, n =(More)
Antenatal maternal stress has been shown in rodent models and in humans to result in altered behavioral and neuroendocrine responses, yet little is known about its effects on functional brain activation. Pregnant female rats received a daily foot-shock stress or sham-stress two days after testing plug-positive and continuing for the duration of their(More)
Two patients with solitary plasmacytoma of the sternum were treated with primary surgical resection. Good long-term results were obtained. There is no long-term documentation that primary radiotherapy alone is the treatment of choice for solitary plasmacytomas. An individualized approach is warranted, especially when there is an isolated bulky lesion(More)
Cryosectioned tissues from snap-frozen samples offer the advantage of preserving proteins at the cellular and subcellular levels and maintaining overall cell integrity in the tissue of interest without the use of chemical fixatives. To prevent specific or nonspecific degradation of proteins by autolytic and/or proteolytic processes, it is common practice to(More)
The optimal method of protecting the spinal cord and viscera during the resection of aneurysms of the descending thoracic aorta is controversial, and some surgeons have recently abandoned shunting and bypass techniques. We are concerned that this may not be the safest approach in most surgeon's hands and have reviewed our experience with a consecutive(More)