Theodore Lamson

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OBJECTIVES The study evaluated a nonsurgical means of intramyocardial cell introduction using the coronary venous system for direct myocardial access and cell delivery. BACKGROUND Direct myocardial cell repopulation has been proposed as a potential method to treat heart failure. METHODS We harvested bone marrow from Yorkshire swine (n = 6; 50 to 60 kg),(More)
A new mock circulatory loop was developed for hemolysis studies associated with the Penn State electric ventricular assist device (EVAD). This flow loop has several advantages over previously designed loops. It is small enough to accommodate experiments in which only single units of blood are available, it is made out of biocompatible materials, it(More)
A technique for real-time in vitro observation of cavitation on a prosthetic heart valve operating in a ventricular assist device under normal physiologic conditions has been developed. Considering the documented observation of cavitation erosion in heart valve components from human explants, and the potential risk of blood damage that cavitation presents,(More)
A method for real-time in vitro observation of cavitation on a prosthetic heart valve has been developed. Cavitation of four blood analog fluids (distilled water, aqueous glycerin, aqueous polyacrylamide, and aqueous xanthan gum) has been documented for a Medtronic/Hall prosthetic heart valve. This method employed a Penn State Electrical Ventricular Assist(More)
A two-phase fluid (TPF) volume compensation chamber (VCC), using Freon as a working fluid, has been developed to reduce pressure fluctuations created in electric ventricular assist devices (VADs) during emptying and filling of the blood sac. The advantages of a TPF VCC over the currently employed flexible compliance chambers are as follows: 1) the TPF VCC(More)
Vapor cavities produced by low pressure fluid flow conditions have been observed in the vicinity of mechanical heart valves for many years. As cavities collapse during pressure recovery, they can produce stresses large enough to cause pitting of the valve occluders and lysing or activation of blood cells. To date, no method has been presented for the(More)
Blood flow through a prosthetic heart valve operating in a ventricular assist device can be subdivided into three phases: a) forward flow through an open valve, b) rapid valve closure, and c) regurgitant back flow through a closed valve. Recent studies of fluid stresses in the Penn State Electric Left Ventricular Assist Device (PS LVAD) operating under(More)
A volume compensation chamber is a device used to reduce large pressure fluctuations created in electric ventricular assist devices during the emptying and filling of the blood sac. In this study, the effect of motor casing pressure variation (pressure swing) on the performance of the Penn State electric ventricular assist device (EVAD) was investigated.(More)
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