Theodore Greene

Learn More
Brain-derived neurotrophic factor (BDNF) has been shown to promote the survival of developing motor neurons in vitro and to rescue motor neurons from axotomy-induced cell death in vivo. In this study, we examined the effects of exogenous BDNF on the progression of wobbler mouse motor neuron disease (MND). After clinical diagnosis at age 3 to 4 weeks, 20(More)
Ciliary neurotrophic factor is the first neurotrophic factor to show survival-promoting effects in developing motor neurons in vitro, in ovo, and in vivo. In the present study we tested the effects of recombinant rat or human ciliary neurotrophic factor in the wobbler mouse model of motor neuron disease. Mice received 1 mg/kg of the factor or a vehicle(More)
We investigated the histological effects of ciliary neurotrophic factor on degenerating motor neurons, their axons, and skeletal muscles in 68 wobbler mice with motor neuron disease. Treatment consisted of recombinant rat or human ciliary neurotrophic factor (or a vehicle solution), 1-mg/kg subcutaneous injection, three times per week for 4 weeks after the(More)
  • Albers Jw, Herman Wh, R Pop-Busui, Feldman El, Martin Cl, Cleary Pa +70 others
  • 2012
Effect of prior intensive insulin treatment during the Diabetes Control andComplications Trial (DCCT) on peripheral neuropathy in type 1 diabetes duringthe Epidemiology of Diabetes Interventions and Complications (EDIC) Study. Mast cell phenotype, location, and activation in severe asthma: data from thesevere asthma research program. 25-hydroxyvitamin D(More)
  • 1