Theodore Brown

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BACKGROUND Clinical studies suggested that fampridine (4-aminopyridine) improves motor function in people with multiple sclerosis. This phase III study assessed efficacy and safety of oral, sustained-release fampridine in people with ambulatory deficits due to multiple sclerosis. METHODS We undertook a randomised, multicentre, double-blind, controlled(More)
The deposition of gadolinium through ultrasound-induced blood-brain barrier (BBB) openings in the murine hippocampus was investigated. First, wave propagation simulations through the intact mouse skull revealed minimal beam distortion while thermal deposition simulations, at the same sonication parameters used to induce BBB opening in vivo, revealed(More)
One of the main goals of sensor networks is to provide accurate information about a sensing field for an extended period of time. This requires collecting measurements from as many sensors as possible to have a better view of the sensor surroundings. However, due to energy limitations and to prolong the network lifetime, the number of active sensors should(More)
OBJECTIVE A previous phase 3 study showed significant improvement in walking ability in multiple sclerosis (MS) patients treated with oral, extended-release dalfampridine (4-aminopyridine) 10mg twice daily. The current study was designed to confirm efficacy and further define safety and pharmacodynamics. METHODS This was a 39-center, double-blind trial in(More)
When a sensor network is deployed, it is typically required to support multiple simultaneous missions. Schemes that assign sensing resources to missions thus become necessary. In this article, we formally define the sensor-mission assignment problem and discuss some of its variants. In its most general form, this problem is NP-hard. We propose algorithms(More)
When a sensor network is deployed in the field, it is typically required to support multiple simultaneous missions, which may start and finish at different times. Schemes that match sensor resources to mission demands thus become necessary. In this paper, we propose centralized and distributed schemes to assign sensors to missions. We also adapt our(More)
It is the coexistence of physical and cognitive impairments, together with emotional and social issues in a disease with an uncertain course, that makes MS rehabilitation unique and challenging. Inpatient rehabilitation improves functional independence but has only limited success improving the level of neurologic impairment. Benefits are usually not long(More)
OBJECTIVES To evaluate the evolutional changes in disease and nonbattle injury in a long-term deployment setting, we investigated trends of selected disease and nonbattle injury (NBI) incidence among US military personnel deployed in ongoing military operations in Southwest Asia and the Middle East. METHODS Participants completed an anonymous(More)
Positioning disk-shaped sensors to optimize certain coverage parameters is a fundamental problem in ad hoc sensor networks. The hexagon lattice arrangement is known to be optimally efficient in the plane, even though 20.9% of the area is unnecessarily covered twice, however, the arrangement is very rigid—any movement of a sensor from its(More)