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The purpose of this study was to validate automated atherosclerotic plaque measurements in carotid arteries from CT angiography (CTA). We present an automated method (three initialization points are required) to measure plaque components within the carotid vessel wall in CTA. Plaque components (calcifications, fibrous tissue, lipids) are determined by(More)
RATIONALE AND OBJECTIVES A method is presented to track guide wires during endovascular interventions under X-ray fluoroscopy. Accurate guide wire tracking can be used to improve guide wire visualization in the low quality fluoroscopic images, and to estimate the position of the guide wire in world coordinates for navigation purposes. MATERIALS AND(More)
PURPOSE To investigate the feasibility of navigation with three-dimensional (3D) rotational radiographic data for transpedicular percutaneous needle introduction and to compare navigation with 3D rotational radiographic data with conventional fluoroscopic guidance. MATERIALS AND METHODS A navigation system was coupled to a 3D rotational radiographic(More)
PURPOSE To investigate the feasibility of using deformable registration in clinical practice to fuse MR and CT images of the head and neck for treatment planning. METHOD AND MATERIALS A state-of-the-art deformable registration algorithm was optimized, evaluated, and compared with rigid registration. The evaluation was based on manually annotated anatomic(More)
Wall shear stress, the force per area acting on the lumen wall due to the blood flow, is an important biomechanical parameter in the localization and progression of atherosclerosis. To calculate shear stress and relate it to atherosclerosis, a 3D description of the lumen and vessel wall is required. We present a framework to obtain the 3D reconstruction of(More)
PURPOSE The degree of stenosis is an important biomarker in assessing the severity of cardiovascular disease. The purpose of our work is to develop and evaluate a semiautomatic method for carotid lumen segmentation and subsequent carotid artery stenosis quantification in CTA images. METHODS The authors present a semiautomatic stenosis detection and(More)
PURPOSE An automatic method for 3D prostate segmentation in magnetic resonance (MR) images is presented for planning image-guided radiotherapy treatment of prostate cancer. METHODS A spatial prior based on intersubject atlas registration is combined with organ-specific intensity information in a graph cut segmentation framework. The segmentation is tested(More)
Using three-dimensional rotational X-ray angiography (3DRA), three-dimensional (3-D) information of the vasculature can be obtained prior to endovascular interventions. However, during interventions, the radiologist has to rely on fluoroscopy images to manipulate the guide wire. In order to take full advantage of the 3-D information from 3DRA data during(More)
Transglutaminases play an important role in vascular smooth muscle cell-induced calcification in vitro. In this study, we determined whether these enzymes are also involved in human atherosclerotic calcification using nine carotid artery specimens obtained at endarterectomy. Sections of the carotid artery specimens were registered to micro-computed(More)
PURPOSE To determine the reproducibility, accuracy, and predictors of accuracy of computed tomography (CT) angiography to detect and characterize coronary atherosclerotic plaque as compared with intravascular ultrasound. METHODS Ten ex vivo human coronary arteries were imaged in a moving phantom by dual-source CT (collimation: 0.6 mm, reconstructed slice(More)