Theo M. de Kok

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Somatostatin analogues can suppress the secretion of some gastrointestinal hormones and growth factors involved in the growth regulation of gastrointestinal cancers and can inhibit the growth of experimental pancreatic tumours. Therefore, in a phase II study 34 patients with metastatic pancreatic (n = 14), colorectal (n = 16) and gastric cancer (n = 4) were(More)
MOTIVATION Comparing time courses of gene expression with time courses of phenotypic data may provide new insights in cellular mechanisms. In this study, we compared the performance of five pattern recognition methods with respect to their ability to relate genes and phenotypic data: one classical method (k-means) and four methods especially developed for(More)
In order to assess the characteristics of malignant breast lesions those were not detected during screening by MR imaging. In the Dutch MRI screening study(MRISC), a non-randomized prospective multicenter study,women with high familial risk or a genetic predisposition for breast cancer were screened once a year by mammography and MRI and every 6 months with(More)
The appearance of malignant lesions in BRCA1 and BRCA2 mutation carriers (BRCA-MCs) on mammography and magnetic resonance imaging (MRI) was evaluated. Thus, 29 BRCA-MCs with breast cancer were retrospectively evaluated and the results compared with an age, tumor size and tumor type matched control group of 29 sporadic breast cancer cases. Detection rates on(More)
Arsenic is an established human carcinogen, but the mechanisms through which it contributes to for instance lung cancer development are still unclear. As arsenic is methylated during its metabolism, it may interfere with the DNA methylation process, and is therefore considered to be an epigenetic carcinogen. In the present study, we hypothesize that arsenic(More)
MOTIVATION Microscopy imaging is an essential tool for medical diagnosis and molecular biology. It is particularly useful for extracting information about disease states, tissue heterogeneity and cell specific parameters such as cell type or cell size from biological specimens. However, the information obtained from the images is likely to be subjected to(More)
The development of biomarkers based on high-throughput techniques, cutting-edge biostatistics and bioinformatics tools is revolutionizing molecular cancer epidemiology. Once validated, such biomarkers will open new and promising perspectives for human health risk assessment and identification of at-risk populations. The application of OMICS to environmental(More)
Objectives : To evaluate diffusion-weighted imaging (DWI) with low b factors of the peripheral zone (PZ) of patients with prostatic cancer. Materials and methods : An EPI diffusion MR sequence (TE = 75 ms, TR = 4000 ms, slice thickness = 4 mm), with low diffusion factors incremented by 10 s/mm 2 , has been developed on a 1.5 T magnet. Axial T2-weighted(More)
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