Theo G. Seiler

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PURPOSE In animal eyes, a significant increase in corneal biomechanical stiffness has been found after collagen crosslinking by combined riboflavin/ultraviolet-A (UVA) treatment. The aim of the present study was to evaluate the clinical usefulness of riboflavin/UVA-induced collagen crosslinking for bringing the progression of keratoconus to a halt. DESIGN(More)
PURPOSE To evaluate the biomechanical effect of combined riboflavin-ultraviolet A (UVA) treatment on porcine and human corneas. SETTING Department of Ophthalmology, Technical University of Dresden, Dresden, Germany. METHODS Corneal strips from 5 human enucleated eyes and 20 porcine cadaver corneas were treated with the photosensitizer riboflavin and(More)
PURPOSE To study potential damage to ocular tissue during corneal collagen cross-linking (X-linking) by means of the riboflavin/UVA (370 nm) approach. METHODS Comparison of the currently used technique with officially accepted guidelines regarding direct UV damage and the damage created by the induced free radicals (photochemical damage). RESULTS The(More)
PURPOSE To evaluate the complication rate of corneal crosslinking (CXL) for primary keratectasia and to develop recommendations for avoiding complications. SETTING Institut für Refraktive und Ophthalmo-Chirurgie, Zurich, Switzerland. METHODS In a prospective study, eyes with verified progressive keratectasia had standard CXL. Preoperative and 6- and(More)
PURPOSE To evaluate the possible cytotoxic effect of combined riboflavin-ultraviolet-A (UVA) treatment on the corneal endothelium. SETTING Department of Ophthalmology, Technical University of Dresden, Dresden, Germany. METHODS The right eyes of 34 New Zealand White rabbits were treated with riboflavin and various endothelial UVA doses ranging from 0.16(More)
BACKGROUND We were able to show a significant increase in corneal stiffness of rabbit and porcine eyes after combined riboflavin/UVA-induced collagen cross-linking. In this study,we tried to treat keratoconus patients with this method to stop the progression of corneal ectasia. PATIENTS AND METHODS We treated 16 eyes of 15 patients with progressive(More)
PURPOSE To report refractive, topographic, tomographic, and aberrometric outcomes 12 months after corneal cross-linking (CXL) in eyes with progressive advanced keratoconus. DESIGN Prospective, nonrandomized, single-center clinical study. PARTICIPANTS Twenty-eight eyes undergoing CXL between April and June 2006. INTERVENTION Riboflavin-ultraviolet A(More)
PURPOSE Combined riboflavin/UVA treatment inducing collagen cross-links in the cornea has been shown to increase the biomechanical rigidity of the cornea and has been used successfully in the treatment of progressive keratoconus. The current study was undertaken to investigate the possible cytotoxic effect of combined riboflavin/UVA treatment on corneal(More)
The 1-year results obtained in 193 eyes of 146 patients who were enrolled in a prospective study investigating photorefractive keratectomy for myopia correction with the excimer laser are reported. Because of lost follow-up (17 eyes) and reoperations (15 eyes), a complete 1-year follow-up was available in 161 eyes of 115 patients that were included in the(More)