Thelma Beatriz González-Castro

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BACKGROUND The polymorphism rs6313 (T102C) has been associated with suicidal behavior in case-control and meta-analysis studies, but results and conclusions remain controversial. The aim of the present study was to examine the association between T102C with suicidal behavior in a case-control study and, to assess the combined evidence - this case-control(More)
INTRODUCTION The gene encoding the serotonin 1A receptor (5HTR1A) has been a candidate gene associated with suicidal behavior in case-control and meta-analysis studies. We carried out a meta-analysis and a case-control study on the 5HTR1A gene to examine the association of this gene with suicidal behavior. METHODS We performed a systematic search in(More)
BACKGROUND It is widely acknowledged that suicidal behavior (SB) has a genetic influence. As a consequence, molecular genetic studies have been mostly conducted on serotonergic genes. One of the most promising candidate genes of this system is tryptophan hydroxylase (TPH). Although there have been several positive studies associating TPH genes and SB, the(More)
INTRODUCTION Schizophrenia affects between 0.3% and 2% of the worldwide population. A genetic contribution has been postulated in the development of this disorder. Genes such as ApoE have been implicated in the neurodevelopment associated with schizophrenia in case-control and meta-analysis studies, but the results remain inconclusive. Due to this, the aim(More)
OBJECTIVE The aim of the present study was to analyse demographic and clinical characteristics, as well as psychiatric diagnoses to identify gender differences in patients with attempted suicide in a Mexican population. METHODS Between September 2010 and September 2012, 140 suicide attempts were documented in the Department of Psychiatry at the General(More)
BACKGROUND Worldwide, the suicide rate is decreasing. To examine changes in the rates of completed suicide in the Mexican population from 2003 to 2012, we analyzed these changes according to: (i) the method of suicide; (ii) age group and (iii) gender. METHODS The data analyzed were obtained from governmental organizations from the State of Tabasco,(More)
The meta-analysis study is a type of systematic review with strong scientific rigor; it has a number of characteristics that makes it a very useful tool. However, performing and reading meta-analysis could be a challenge-the meta-analysis overcomes the limitation of small sample sizes or rare outcomes by pooling results from individual studies in order to(More)
BACKGROUND The C-reactive protein (CRP) and the tumor necrosis factor-alpha (TNF-α) are considered markers of inflammation and have been shown to predict the risk of incident cardiovascular events. However, few studies have undertaken a comprehensive examination of SNPs (single nucleotide polymorphisms) of the CRP and TNF-α genes; due to this, we will(More)
BACKGROUND Suicidal behavior is a leading cause of injury and death worldwide. Several studies have provided a possible relationship between genetic factors and suicidal behavior. Also, these studies have shown evidence for altered serotonergic neural transmission in the pathogenesis of suicidal behavior. In addition, genes pertaining to the serotonergic(More)