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Polycomb proteins are epigenetic regulators that localize to developmental loci in the early embryo where they mediate lineage-specific gene repression. In Drosophila, these repressors are recruited to sequence elements by DNA binding proteins associated with Polycomb repressive complex 2 (PRC2). However, the sequences that recruit PRC2 in mammalian cells(More)
BACKGROUND Vascular endothelial growth factor (VEGF) is upregulated in pulmonary alveolarization. However, developmental expression of pulmonary VEGF and its possible role in the pathogenesis of CDH are not well described. METHODS Timed-pregnant VEGF-LacZ mice, possessing a beta-galactosidase reporter introduced into the 3' region of the VEGF gene, were(More)
Wilms tumor is the most common pediatric kidney cancer. To identify transcriptional and epigenetic mechanisms that drive this disease, we compared genome-wide chromatin profiles of Wilms tumors, embryonic stem cells (ESCs), and normal kidney. Wilms tumors prominently exhibit large active chromatin domains previously observed in ESCs. In the cancer, these(More)
We have developed a method for direct, copper-catalyzed, auxiliary-assisted fluorination of β-sp(2) C-H bonds of benzoic acid derivatives and γ-sp(2) C-H bonds of α,α-disubstituted benzylamine derivatives. The reaction employs a CuI catalyst, a AgF fluoride source, and DMF, pyridine, or DMPU solvent at moderately elevated temperatures. Selective mono- or(More)
We present an approach for scalable processing of SPARQL queries to RDF views of numerical data stored in relational databases (RDBs). Such queries include numerical expressions, inequalities, comparisons, etc. inside FILTERs. We call such FILTERs numerical expressions and the queries-numerical SPARQL queries. For scalable execution of numerical SPARQL(More)
Our implementation of the DEBS 2013 Challenge is based on a scalable, parallel, and extensible DSMS, which is capable of processing general continuous queries over high volume data streams with low delays. A mechanism to provide user defined incremental aggregate functions over sliding windows of data streams provide real-time processing by emitting results(More)
Main-memory database systems (MMDBs) are viable solutions for many scientific applications. Scientific and engineering data often require special indexing methods, and there is a large number of domain specific main memory indexing implementations developed. However, adding an index structure into a database system can be challenging. <i>Mexima</i>(More)