Thanh Truong

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Polycomb proteins are epigenetic regulators that localize to developmental loci in the early embryo where they mediate lineage-specific gene repression. In Drosophila, these repressors are recruited to sequence elements by DNA binding proteins associated with Polycomb repressive complex 2 (PRC2). However, the sequences that recruit PRC2 in mammalian cells(More)
Wilms tumor is the most common pediatric kidney cancer. To identify transcriptional and epigenetic mechanisms that drive this disease, we compared genome-wide chromatin profiles of Wilms tumors, embryonic stem cells (ESCs), and normal kidney. Wilms tumors prominently exhibit large active chromatin domains previously observed in ESCs. In the cancer, these(More)
We present an approach for scalable processing of SPARQL queries to RDF views of numerical data stored in relational databases (RDBs). Such queries include numerical expressions, inequalities, comparisons, etc. inside FILTERs. We call such FILTERs numerical expressions and the queries numerical SPARQL queries. For scalable execution of numerical SPARQL(More)
Main-memory database systems (MMDBs) are viable solutions for many scientific applications. Scientific and engineering data often require special indexing methods, and there is a large number of domain specific main memory indexing implementations developed. However, adding an index structure into a database system can be challenging. <i>Mexima</i>(More)
We have developed a method for direct, copper-catalyzed, auxiliary-assisted fluorination of β-sp(2) C-H bonds of benzoic acid derivatives and γ-sp(2) C-H bonds of α,α-disubstituted benzylamine derivatives. The reaction employs a CuI catalyst, a AgF fluoride source, and DMF, pyridine, or DMPU solvent at moderately elevated temperatures. Selective mono- or(More)
Our implementation of the DEBS 2013 Challenge is based on a scalable, parallel, and extensible DSMS, which is capable of processing general continuous queries over high volume data streams with low delays. A mechanism to provide user defined incremental aggregate functions over sliding windows of data streams provide real-time processing by emitting results(More)
Two reactions of phenols with arynes have been developed. If LiTMP base is employed, arynes generated from aryl chlorides react with phenols to form helicenes. o-Arylation of phenols can be achieved by employing tBuONa base in the presence of AgOAc. Direct arylation of binol was achieved leading to the shortest pathway to o,o'-diarylbinols.
We analyse the determinants of equity agency costs for the top 500 Australian listed firms. Data are collected over four one-year periods (2004, 2005, 2010 and 2011) and analysed using both pooled OLS regression and two stage least squares regression within a random effects panel data model. Analysis covers the full four-year period, the pre global(More)