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Polycomb proteins are epigenetic regulators that localize to developmental loci in the early embryo where they mediate lineage-specific gene repression. In Drosophila, these repressors are recruited to sequence elements by DNA binding proteins associated with Polycomb repressive complex 2 (PRC2). However, the sequences that recruit PRC2 in mammalian cells(More)
Wilms tumor is the most common pediatric kidney cancer. To identify transcriptional and epigenetic mechanisms that drive this disease, we compared genome-wide chromatin profiles of Wilms tumors, embryonic stem cells (ESCs), and normal kidney. Wilms tumors prominently exhibit large active chromatin domains previously observed in ESCs. In the cancer, these(More)
We present an approach for scalable processing of SPARQL queries to RDF views of numerical data stored in relational databases (RDBs). Such queries include numerical expressions, inequalities, comparisons, etc. inside FILTERs. We call such FILTERs numerical expressions and the queries-numerical SPARQL queries. For scalable execution of numerical SPARQL(More)
Main-memory database systems (MMDBs) are viable solutions for many scientific applications. Scientific and engineering data often require special indexing methods, and there is a large number of domain specific main memory indexing implementations developed. However, adding an index structure into a database system can be challenging. <i>Mexima</i>(More)
Our implementation of the DEBS 2013 Challenge is based on a scalable, parallel, and extensible DSMS, which is capable of processing general continuous queries over high volume data streams with low delays. A mechanism to provide user defined incremental aggregate functions over sliding windows of data streams provide real-time processing by emitting results(More)
A potential problem for persisting large volume of streaming logs with conventional relational databases is that loading large volume of data logs produced at high rates is not fast enough due to the strong consistency model and high cost of indexing. As a possible alternative, state-of-the-art NoSQL data stores that sacrifice transactional consistency to(More)