Thanh Huan Vuong

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O6-Benzyl-2'-deoxyguanosine (O6-BzldGuo) was found to be a potent inhibitor of O6-methylguanine-DNA methyltransferase (MGMT) activity in vivo, despite its demonstrated lower activity compared to O6-benzylguanine (O6-BzlGua) for inactivation of MGMT in cell cultures or cell free extracts. This difference is probably due to metabolism and possibly to enhanced(More)
Methionine (MET)-dependent cell lines require MET to proliferate, and homocysteine (HCY) does not act as a substitute for this requirement. From six O6-methylguanine-DNA methyltransferase (MGMT)-efficient (mer+) cell lines tested, two medulloblastomas (Daoy and D-341) and a lung non-small-cell adenocarcinoma with metastatic potential (H-1623) were most(More)
The relationship between the birthweight of newborn infants and their mothers' health characteristics as well as socio-economic status were studied in 1474 consecutive deliveries from eight areas in the delta region of north Vietnam. The results showed that the proportion of low birthweight (LBW) infants varied from 7.9% to 12.5%. Body mass index (BMI) of(More)
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