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Cereblon (CRBN), a substrate receptor for the cullin-RING ubiquitin ligase 4 (CRL4) complex, is a direct protein target for thalidomide teratogenicity and antitumor activity of immunomodulatory drugs (IMiDs). Here we report that glutamine synthetase (GS) is an endogenous substrate of CRL4(CRBN). Upon exposing cells to high glutamine concentration, GS is(More)
In a cognitive radio network, opportunistic spectrum access (OSA) to the underutilized spectrum involves not only sensing the spectrum occupancy but also probing the channel quality in order to identify an idle and good channel for data transmission-particularly if a large number of channels is open for secondary spectrum reuse. Although such a joint(More)
In this paper, we consider a wideband cognitive radio network with limited available frame energy and treat a fundamental energy allocation problem: how available energy should be optimally allocated for sensing, probing, and data transmission to maximize the achievable average opportunistic spectrum access (OSA) throughput. By casting this problem into the(More)
In this paper, we consider secure communication over a multiple-input single-output Rayleigh-fading channel in the presence of a multiple-antenna eavesdropper - referred to as a multiple-input single-output multiple-eavesdropper (MISOME) wiretap channel. Specifically, secure beamforming with artificial noise is treated when the transmitter has access to(More)