Thalia Shoshana Field

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OPINION STATEMENT Though antiplatelet agents are the mainstay of antithrombotic therapy for secondary prevention of noncardioembolic cerebral ischemic events, the efficacy of combination aspirin and clopidogrel has yet to be clarified by clinical trials. Current evidence suggests that there is no role for long-term combination of aspirin/clopidogrel for(More)
BACKGROUND Changes in weather and season have been linked to stroke occurrence. However, the association has been inconsistent across stroke types. Calgary is a city in the Chinook belt and is subject to high variability in weather conditions. METHODS We obtained hourly weather data over a 5-year period from 1996 to 2000; Chinook events were identified(More)
Background-—The role of the CYP2C19 genotype on clopidogrel efficacy has been studied widely, with data suggesting reduced clopidogrel efficacy in loss-of-function variant carriers taking clopidogrel after percutaneous coronary intervention; however, data are limited regarding the association between CYP2C19 genetic variants and outcomes in stroke patients.(More)
BACKGROUND Pain is a common complication after stroke and is associated with the presence of depression, cognitive dysfunction, and impaired quality of life. It remains underdiagnosed and undertreated, despite evidence that effective treatment of pain may improve function and quality of life. SUMMARY We provide an overview of the means for clinical(More)
BACKGROUND Stroke incidence has fallen since 1950. Recent trends suggest that stroke incidence may be stabilizing or increasing. We investigated time trends in stroke occurrence and in-hospital morbidity and mortality in the Calgary Health Region. METHODS All patients admitted to hospitals in the Calgary Health Region between 1994 and 2002 with a primary(More)
BACKGROUND Stroke occurrence appears to be a random event, yet annual and supra-annual periodicity is observed. Recent attention in atherosclerotic disease etiology has focused on infectious and inflammatory mechanisms. Influenza is one such infection that may influence stroke occurrence. METHODS We explored population-based time series data on stroke(More)
It is unknown whether relations between early-life factors and overall health in later life apply to burden of cerebral small vessel disease (cSVD), a major cause of stroke and dementia. We explored relations between early-life factors and cSVD in the Lothian Birth Cohort, a healthy aging cohort. Participants were recruited at age 70 (N = 1091); most had(More)
BACKGROUND Associations have been reported between gastroesophageal reflux and a variety of upper and lower respiratory tract conditions. Respiratory conditions and GER are common and would be expected to coexist in many patients. Whether there is a relationship between GER and these conditions and its nature remain controversial. The purpose of this paper(More)
Atrial fibrillation accounts for a substantial proportion of ischemic strokes of known etiology and may be responsible for an additional subset of the 25-40% of strokes of unknown cause (so-called cryptogenic). Oral anticoagulation is significantly more effective than antiplatelet therapy in the secondary prevention of atrial fibrillation-related strokes,(More)
Noreen Kamal, PhD, PEng; Michael D. Hill, MD, MSc, FRCPC; Dylan P.V. Blacquiere, MD, MSc, FRCPC; Jean-Martin Boulanger, MD, FRCPC; Karl Boyle, MB, BCh, BAO, MRCPE, MSc (Stroke Med); Brian Buck, MD, FRCPC; Kenneth Butcher, MD, FRCPC; Marie-Christine Camden, MD, FRCPC; Leanne K. Casaubon, MD, MSc, FRCPC; Robert Côté, MD, FRCPC; Andrew M. Demchuk, MD, FRCPC;(More)