- Full text PDF available (2)
—We present an innovative microfluidic system that accomplishes specific capture, enrichment, and isocratic elu-tion of biomolecular analytes with coupling to label-free mass spectrometric detection. Analytes in a liquid phase are specifically captured and enriched via their affinity binding to ap-tamers, which are immobilized on microbeads packed inside a… (More)
This paper demonstrates and systematically characterizes the enrichment of biomolecular compounds using aptamer-functionalized surfaces within a microfluidic device. The device consists of a microchamber packed with aptamer-functionalized microbeads and integrated with a microheater and temperature sensor to enable thermally controlled binding and release… (More)
This article presents a method of designing non-linear feedback controller which both compensates non-linear character of two degree of freedom robot to become equivalent linear plant and implement direct channel separation thereby easily apply linear theory to design state feedback controller.