Thai Huu Nguyen

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—We present an innovative microfluidic system that accomplishes specific capture, enrichment, and isocratic elu-tion of biomolecular analytes with coupling to label-free mass spectrometric detection. Analytes in a liquid phase are specifically captured and enriched via their affinity binding to ap-tamers, which are immobilized on microbeads packed inside a(More)
This paper demonstrates and systematically characterizes the enrichment of biomolecular compounds using aptamer-functionalized surfaces within a microfluidic device. The device consists of a microchamber packed with aptamer-functionalized microbeads and integrated with a microheater and temperature sensor to enable thermally controlled binding and release(More)
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