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Many studies of monozygotic (MZ) twins have revealed evidence of genetic influences on intellectual functions and their derangement in certain neurologic and psychiatric diseases afflicting the forebrain. Relatively little is known about genetic influences on the size and shape of the human forebrain and its gross morphologic subdivisions. Using MRI and(More)
OBJECTIVE To evaluate the use of healthcare resources during the last six months of life among patients of US hospitals with strong reputations for high quality care in managing chronic illness. DESIGN Retrospective cohort study based on claims data from the US Medicare programme. PARTICIPANTS Cohorts receiving most of their hospital care from 77(More)
BACKGROUND National estimates of the upcoming diabetes epidemic are needed to understand the distribution of diabetes risk in the population and to inform health policy. OBJECTIVE To create and validate a population-based risk prediction tool for incident diabetes using commonly collected national survey data. METHODS With the use of a cohort design(More)
BACKGROUND Despite universal health care, there continues to be regional access disparities to coronary angiography in Canada. Our objective was to evaluate the extent to which demand-side factors such as clinical urgency/need, and supply-side factors, as reflected by differences in physician and procedural supply account for these inequalities. METHODS(More)
BACKGROUND Although the relation between hospital volume and surgical mortality is well established, for most procedures, the relative importance of the experience of the operating surgeon is uncertain. METHODS Using information from the national Medicare claims data base for 1998 through 1999, we examined mortality among all 474,108 patients who(More)
BACKGROUND The health implications of regional differences in Medicare spending are unknown. OBJECTIVE To determine whether regions with higher Medicare spending achieve better survival, functional status, or satisfaction with care. DESIGN Cohort study. SETTING National study of Medicare beneficiaries. PATIENTS Patients hospitalized between 1993 and(More)
BACKGROUND Atypical antipsychotic agents are thought to be less likely than older typical agents to produce parkinsonism. This has not been well documented. We compared the risk of development of incident parkinsonism among older adults dispensed atypical relative to typical antipsychotics. METHODS Retrospective cohort study of all adults 66 years and(More)
OBJECTIVE To determine whether patients who are not admitted to hospital after attending an emergency department during shifts with long waiting times are at risk for adverse events. DESIGN Population based retrospective cohort study using health administrative databases. Setting High volume emergency departments in Ontario, Canada, fiscal years 2003-7.(More)
BACKGROUND Non-selective, non-steroidal anti-inflammatory drugs (NSAIDs) are associated with an increased risk of congestive heart failure, but little is known about the cardiovascular effects of a newer group of NSAIDS called selective cyclo-oxygenase (COX)-2 inhibitors. We aimed to compare rates of admission for congestive heart failure in elderly(More)