Tetyana Dodatko

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BACKGROUND The first step of the bacterial lifecycle is the germination of bacterial spores into their vegetative form, which requires the presence of specific nutrients. In contrast to closely related Bacillus anthracis spores, Bacillus cereus spores germinate in the presence of a single germinant, inosine, yet with a significant lag period. METHODS AND(More)
Cyclase-associated protein (CAP or Srv2p) is a modular actin monomer binding protein that directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity. The crystal structure of the C-terminal dimerization and actin monomer(More)
The inhibition of cysteine biosynthesis in prokaryotes and protozoa has been proposed to be relevant for the development of antibiotics. Haemophilus influenzae O-acetylserine sulfhydrylase (OASS), catalyzing l-cysteine formation, is inhibited by the insertion of the C-terminal pentapeptide (MNLNI) of serine acetyltransferase into the active site.(More)
We have tested a series of inosine analogs for their effect on germinating B. cereus 569 spores. Our results showed that although inosine (hypoxanthine nucleoside) causes spore germination by itself, the kinetic pathway exhibited complex and strongly cooperative character. Contrary to inosine’s germinating effect, the purine pathway degradation products(More)
Bacillus cereus 569 spores germinate either with inosine as a sole germinant or with a combination of nucleosides and L-alanine. Whereas the inosine-only germination pathway requires the presence of two different germination receptors (GerI and GerQ) to be activated, the nucleoside/alanine germination pathway only needs one of the two receptors. To(More)
The ability of 46 strains of Pseudomonas cepacia to inhibit phytopathogenic fungi and the effect of iron on their antifungal activity were studied. The antifungal effect of the bacteria and the antimicrobial activity of their crude yellow and violet pigments showed a 4-5-fold decrease in the presence of Fe(III). The addition of 100 micrograms/ml of FeCl3 to(More)
Pseudomonas cepacia 5779 bacteriocin (cepaciacin) whose producer was revealed due to application of the special screening system has been studied for its certain biological and physicochemical properties. Possessing a narrow range of action, it inhibits only the P. cepacia strains. Its biosynthesis occurs more intensely on the rich nutrient media, the(More)
Occurrence of bacteriocinogeneity in 120 strains of 24 species of Pseudomonas was studied. Active strains producing bacteriocine-like substances were detected among P. fluorescens, P. putida, P. taetrolens, P. fragi, P. stutzeri, P. mendocina, P. maltophilia, and P. pseudoalcaligenes. The bacteriocine-like substances produced by them differed by the(More)