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IMPORTANCE Ripasudil hydrochloride hydrate (K-115), a novel rho kinase inhibitor, provides statistically significant intraocular pressure (IOP)-lowering effects and has a tolerable safety profile. However, no studies have evaluated ripasudil combined with β-blockers and prostaglandin analogues. OBJECTIVE To evaluate the additive IOP-lowering effects and(More)
— In a frequency reusing wireless local area network (WLAN), the co-channel interference (CCI) environment will change when new access points (APs) join the network. Therefore, the user throughput reduces if the available channels are not properly re-allocated. A newly joined AP is designed to measure the CCI levels on the available channels to select the(More)
The aim of this study was to characterise brain tumour type and treatment response in relation to the uptake of thallium-201.201Tl single photon emission tomography (SPET) was performed in 58 patients with brain tumours. Fifty-six patients were utilised for the statistical comparison of the early and delayed201Tl indices expressed as the ratio of tumour to(More)
IMPORTANCE We conducted a series of phase 1 clinical trials to elucidate the efficacy and safety of the selective Rho kinase inhibitor K-115 as a candidate drug for the treatment of glaucoma. We report the intraocular pressure (IOP)-lowering effects and safety of K-115 based on our results. OBJECTIVE To study the IOP-lowering effects and safety of topical(More)
To inhibit arthritis upstream of inflammatory cytokine release and matrix metalloproteinase (MMP) action, we designed de novo a small-molecule inhibitor of c-Fos/activator protein-1 (AP-1) using three-dimensional (3D) pharmacophore modeling. This model was based on the 3D structure of the basic region-leucine zipper domain of AP-1-DNA complex.(More)
OBJECTIVE To determine the prevalence and causes of low vision and blindness in a Japanese adult population. DESIGN Population-based cross-sectional study. PARTICIPANTS Randomly selected residents (n = 3870) of Tajimi City, Japan, who were 40 years of age or older. METHODS Of the 3021 study participants (78.1% of 3870 eligible persons), 2977 (76.9%)(More)
PURPOSE To identify the optimal dose of a novel Rho kinase inhibitor, K-115, by assessing dose dependency of the intraocular pressure (IOP)-lowering effects and the safety in patients with primary open-angle glaucoma or ocular hypertension. DESIGNS Multicenter, prospective, randomized, placebo-controlled, double-masked, parallel group comparison clinical(More)
For the realization of future wireless networks, gigabit wireless technology, which can achieve higher-than-1 Gbps data transmission with extremely low transmit power, is indispensable. We have been studying the distributed antenna network (DAN) and the frequency domain wireless signal processing. In DAN, many antennas or clusters of antennas are spatially(More)
PURPOSE To assess the prevalence of primary open-angle glaucoma (POAG) and its association with intraocular pressure (IOP) in Tajimi City in central Japan. DESIGN A cross-sectional epidemiologic study in a defined population. PARTICIPANTS Subjects randomly selected from the population older than 40 years in Tajimi City. INTERVENTION Each subject(More)
PURPOSE To evaluate the prevalence of refractive errors associated with age, gender, and central corneal thickness and to evaluate astigmatism in the refraction and keratometry in a randomly sampled elderly Japanese population. DESIGN Population-based epidemiologic survey. PARTICIPANTS A random sampling of residents of Tajimi, Japan, aged 40 years or(More)