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Untargeted Metabolomic Profiling as an Evaluative Tool of Fenofibrate-Induced Toxicology in Fischer 344 Male Rats
Several metabolites related to liver function, kidney function, cell damage, and cell proliferation were altered by fenofibrate-induced toxicity at this dose, suggesting the possibility of oxidative stress as a mechanism of nongenotoxic carcinogenesis. Expand
Ursodeoxycholic acid improves insulin sensitivity and hepatic steatosis by inducing the excretion of hepatic lipids in high-fat diet-fed KK-Ay mice.
Results indicate that UDCA ameliorates hyperglycemia and hyperinsulinemia by improving hepatic insulin resistance and steatosis in high-fat diet-fed KK-A(y) mice. Expand
MALDI Efficiency of Metabolites Quantitatively Associated with their Structural Properties: A Quantitative Structure–Property Relationship (QSPR) Approach
Structural properties of metabolites that contribute to their ionization in MALDI-MS analyses are extracted using a quantitative structure–property relationship (QSPR) approach and it is suggested that the proton affinity is a major determinant of the ionization, whereas some substructures hinder efficient ionization. Expand
Synthesis and properties of GuNA purine/pyrimidine nucleosides and oligonucleotides.
All GuNAs (GuNA-T, -A, -G, and -mC) are now available to be examined in therapeutic applications and some of the GuNA-modified oligonucleotides were revealed to have high base discriminating ability compared with that of their natural counterparts. Expand